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Monday, 05 June
00:45
Large Scale Thread Portraits Are Masterfully Embroidered on Tulle "IndyWatch Feed Arts"
Large Scale Thread Portraits Are Masterfully Embroidered on Tulle
We are accustomed to seeing embroidery made on a small scale, but artist Katerina Marchenko takes this art form and makes it lifesize. Using colorful strands of yarn, she renders massive human portraits on delicate tulle and showcases the endless possibilities this medium has to offer.
Marchenko shows how she approaches each piece via her social media. In these videos, we see her weave long and wide pieces of thread through the tulle using her hands (san needle). She begins by outlining the facial features like the eyes, nose, and mouth with black. Then, she adds various hues to create planes of color, filling the portrait with a sense of dimension. However, rather than trying to disguise her method, she highlights the thread medium by adding stylistic touches to these faces in the form of long loose threads which cascade down the face or radiate from the head.
These large-scale portraits possess similar qualities to expressive paintings. The way in which Marchenko manipulates the array of different colored threads mimics brushstrokes on a canvas. And by alternating between light and dark shades, she even models these human figures.
You can purchase original embroidery creations via Marchenko's Etsy store and keep up to date with her latest creations by following the artist on Instagram.
Artist Katerina Marchenko embroiders large-scale designs on delicate tulle.
...Sunday, 04 June
23:45
Fascinating Animation Compares the Size of Extinct Animas With Their Descendants "IndyWatch Feed Arts"
Fascinating Animation Compares the Size of Extinct Animas With Their Descendants
When we think of the size of extinct animals, our minds might go to the large T-Rex in Jurassic Park. As frightening as that looks, there are other creatures that, while long gone, would've been quite scary to encounter. YouTube channel WTD has created a digital animation showcasing the sizes of extinct animals alongside their extant descendants. Let's just say that some daunting creatures of today had much more intimidating relatives in the long-since past.
The video begins presenting the nuralagus, a yard-length relative of the rabbit. Things, however, quickly escalate from there. For example, while modern beavers are about 17 inches tall, their ancestor, the castoroides, was over three feet tall and eight feet long. The same goes for the Emperor penguin. At four feet tall, they are endearing, but the Anthropornis Nordenskjoeldi was six feet highso basically as tall as a professional basketball player.
Some threatening creatures currently in the world make an appearance alongside their ancestors. The 32-foot reticulated python is joined by the 45-foot titanoboa, while the saltwater crocodile, at about 10 feet long, is four times smaller than the Rhamphosuchus, which was 39 feet long.
The animation also features some creatures that, while almost similar in size to their descendants, had some very distinctive features. This includes the megaloceros' large antlers, which rival the size of a moose, or the arctotherium, a bear almost similar in height to the polar bear but with dark fur and native to Central and South America.
WTD, which is dedicated to collecting and making data comparison of all things in 3D, has also produced some other insightful animations comparing animals present and past. To stay up to date with its videos, you can subscribe to its YouTube channel.
YouTube channel WTD has created a digital animation showcasing the sizes of extinct animals alongside their extant descendants.
23:35
A Chefs Take on the Seasoning Police on Social Media Got People Talking "IndyWatch Feed Arts"
Photo Credit: TikTok
People sure do get worked up about how other folks make their food, huh?
And heres another example of what Im talking aboutand there seems to be some confusion attached to this story, as well.
A chef and food content creator named Zoe Barrie found herself in the middle of a comment war on TikTok after she uploaded a video about the meal she conjured up at her brothers house with whatever she could find in his kitchen.
Photo Credit: TikTok
23:32
2001: A Space Odyssey Bill Coopers esoteric meaning of Stanley Kubricks movie (Part 2) "IndyWatch Feed Spiritual"
2001: A SPACE ODYSSEY - BILL COOPER'S ESOTERIC MEANING OF STANLEY KUBRICK'S MOVIE (PART 2)
https://www.bitchute.com/video/R7ph4rDiYBid/23:24
U.S. CONGRESS HAS RECEIVED JESSIE MARIE CZEBOTARS PETITION TO APPEAR AND TESTIFY "IndyWatch Feed Spiritual"
Below you will find Jessie Marie Czebotars Petition.
~begin~ February 14, 2023 On Behalf of : We The People of
the United States of America Jessie Czebotar Timothy Charles
Holmseth Randi Lynn Erickson United States Congress
Judiciary Committee on Weaponization of Government Attention: Jim
Jordan, Chair Judiciary Committee/ Washington D.C. United States
House of Representatives Attention: Kevin McCarthy Washington D.C.
Attention: Diana Harshbarger (TN) Attention Tim Burchett (TN)
Attention Chuck Fleischmann (TN) Attention Scott DesJarlais (TN)
Jim Jordan Phone: 202-225-2676 Donald J. Trump, 45th
President of the United States Attention to: Trumps Attorneys Peter
Tickton/ 270 SW Natura Ave/ Deerfield Beach, FL 33441 Lindsey
Halligan/ 511 SE 5th Ave/ Fort Lauderdale, FL 3330102984
Florida PART X: INVESTIGATIONS AND PUBLIC ORDER CHAPTER 73:
INVESTIGATIONS BY LEGISLATIVE BODIES Sec 795: Right of Legislative
Body to Make Investigations In the Matter of FEDERAL CASE:
3:22-CV-00912 In RE:
- Middle District of TN/ RICO
- Federal Court Filing in MN District Court/ SEALED Affidavits
- District Court of FL/RICO/ CRIMES AGAINST HUMANITY
23:03
Tron (TRX) Sees 10% Price Surge Following Bittorrent Bridge Launch "IndyWatch Feed Crypto"
Tron (TRX), the native cryptocurrency of the Tron blockchain, witnessed a substantial increase over the weekend. The token spiked by 10% yesterday, buoyed by recent developments within its ecosystem. However, at the time of writing, it has experienced a slight correction, but all signs show that this could be a bullish signal.
Tron Spike Due To Bittorent Bridge Launch
The reason behind this latest surge can be attributed to the recent launch of the BitTorrent Bridge platform, which now allows users to seamlessly transfer their TRX tokens between the Tron blockchain and Ethereum. Justin Sun, the founder of Tron, confirmed this development on the morning of June 2.
The BitTorrent Bridge serves as a decentralized system that facilitates token interoperability across different blockchain networks. Developed by the Tron organization under the leadership of Justin Sun, this platform strengthens the collaborative efforts between BitTorrent and Tron. A notable instance of their collaboration is the BitTorrent Live streaming service, which was launched in 2019 and operates in conjunction with Trons system.
Related Reading: Quant Hype Spikes As Price Surges 15% Is This A Top Signal?
The integration between TRON and Ethereum through the BitTorrent Bridge opens up new possibilities for TRX users while enhancing the interoperability between these prominent blockchains. This breakthrough expands Trons presence within the Ethereum ecosystem and has the potential to drive greater adoption of TRX among Ethereum users.
It is important to note that TRX initially existed as an ERC-20 token on the Ethereum network before being migrated to the TRON main network in mid-2018. Since then, Tron has grown into one of the biggest blockchains and currently processes 40% of USDT transactions.
Related Reading: XRP Climbs 12% As Crypto Celebrates 11-Year Milestone
Tron Price Analysis
Analyzing Trons current price performance, the coin is currently trading at $0.0805. Moreover, Tron has the potential to maintain its position above the moving averages. If the resistance level of $0.085 is breached, it could serve as a catalyst for a bullish trend, potentially leading to further price gains.
The market sentiment appears optimistic as buyers continue to demonstrate a strong commitment. Based on the daily chart analysis, another upward movement in the market price is possible. Therefore, if Tron surpasses the channels upper boundary, it could further reinforce the market and reach resistance levels of $0.095, $0.100, and $0.105, respectively.
...23:01
Cryptocurrency markets low volatility: A curse or an opportunity? "IndyWatch Feed Crypto"
The cryptocurrency market has been experiencing low volatility for the past two months, but does that mean investors should just sit and wait?
22:28
Montauk Project Time Traveler reveals the truth about the last days we are now living in "IndyWatch Feed Spiritual"
22:00
Three Reasons Behind Bitcoin's 2023 Resurgence "IndyWatch Feed Crypto"
This is an opinion editorial by Chen Fang, the COO of BitGO, a Bitcoin-focused regulated custody and financial services firm.
A challenging 2022 prompted Bitcoin skeptics to gleefully say I told you so and declare that Bitcoin was dead and buried. But, much to their chagrin, their victory lap ended up being premature. Bitcoin has come roaring back in 2023, ending these premature celebrations and taking back some of its 2022 losses with a massive year-to-date gain of over 60% as of this writing so far in 2023.
Here are three reasons behind Bitcoins 2023 resurgence:
One: Banking Sector Turmoil And A Timely Reminder Of Bitcoins Value
In March 2023, turmoil from the banking sector in the wake of Silicon Valley Banks collapse rocked the market with the types of issues that it hadnt experienced since the Great Recession. This was no fly-by-night operation; at the time, Silicon Valley Bank (SVB) was the sixteenth-largest bank in the United States and the bank of choice for many venture capitalists and startups.
This high-profile implosion and the lack of proper risk management in place at SVB led many individuals to question how safe their money was. Ultimately, the Federal Reserve stepped in to make the banks depositors whole, but the event still called the health of the banking system into question.
While not everyone is rushing to take their money out of banks, many more people are now at least aware of the risks of a single point of failure and are moving to diversify their assets by splitting them between multiple banks or even diversifying into alternatives like bitcoin and other cryptocurrencies for the first time.
The appeal of a fully decentralized asset like bitcoin is that there is no CEO or management team in charge that can endanger the solvency of the Bitcoin network by making a bad decision or poor judgment call. Bitcoin users dont have to trust a company or management team to use Bitcoin; they can instead verify the open-source code that governs the Bitcoin network. Anyone can view any transaction ever made on the Bitcoin blockchain, giving the network unmatched transparency.
The price of bitcoin surged in March in the wake of the crisis, and in late April, renewed troubles at First Republic Bank, which reported that it...
21:28
5 free ChatGPT and generative AI courses "IndyWatch Feed Crypto"
Level up your skills in language models and automation with free ChatGPT and generative AI courses.
20:48
These Towns Will Actually Pay You to Move There "IndyWatch Feed Arts"
Youre telling me that the folks who run certain towns and cities are willing to actually PAY people to move there?
Well, thats a new one!
And if youve been looking for a change of scenery, you might want to consider one of these places that are handing out some pretty nice bonuses to folks looking to relocate.
Take a look at the list below and see if any of these places suit your fancy.
Topeka, Kansas
The capital city of Kansas will pay people up to $15,000 to move there if their employer participates in a specific program.
Theres an application process and you have to commit to living in Topeka for a year but there are also some employers that will match the money, so its possible to make double the money!
Look into it!
Paducah, Kentucky
Paducah is a small town of about 25,000 people and the folks in charge there are encouraging remote workers to make Paducah their home and theyll reward folks who choose the deal with a package thats...
20:43
The Lion of Chaeronea "IndyWatch Feed Literature"
Trifacial Trinity, anonymous artist (Cusco School), between ca. 1750 and ca. 1770
19:39
Silver colored spheres Sometimes they are semi-translucent. New York Times, 14 December 1944 "IndyWatch Feed Spiritual"
18:59
Pro-XRP attorneys phone hacked to promote LAW token "IndyWatch Feed Crypto"
Lawyer John Deaton alerted followers via his daughters account, urging people to report the hack as the XRP community responded, spreading awareness.
18:22
Cult Conspiracy: US Charges Two in Plot Against Chinese Religious Group "IndyWatch Feed Spiritual"
Two Chinese nationals allegedly acting as agents for the Chinese government were apprehended in the United States following an undercover operation and were charged with trying to damage and topple an anti-communist Chinese religious group.
US charges two over China-backed plot against Falun Gong https://t.co/Rk9UhxXN4v
Al Jazeera English (@AJEnglish) May 27, 2023
Authorities in Los Angeles arrested 70-year-old John Chen and 43-year-old Lin Feng on May 26th, where they were indicted for planning to revoke the tax-exempt status of the New York-based Falun Gong spiritual movement in an attempt to further undermine the exiled group.
The two Chinese nationals were both born in China but lived in Los Angeles at the time of their arrest. Chen is a US citizen, while Feng was described as a lawful permanent resident. Theyre facing charges of being unregistered agents of a foreign government, practicing money laundering, and bribing public officials.
Two Los Angeles residents were arrested for allegedly taking part in a Beijing-directed scheme to disrupt U.S.-based practitioners of Falun Gong, a spiritual movement banned in China for its criticism of the Chinese government https://t.co/gO1Z5rduVi pic.twitter.com/e5yE39uO1q
Reuters (@Reuters) May 27, 2023
Chen and Feng were caught after they initially urged the Internal Revenue Service (IRS) to revoke Falun Gongs non-profit tax status. Chen also described the organization as a gigantic mega cult in his whistleblower complaint that he filed to the tax agency last February, echoing the language used by the Chinese Communist Party (CCP) against the group.
After filing their complaint, an undercover police officer posed as an official for the IRS. According to prosecutors handling their case, Chen met with the officer at a restaurant north of New York City on May 14th.
Chen approached the officer to ensure that the agency would act on their complaint while communicating with h...
18:18
17:47
He Scolded Her For Her Swimsuit Choice. Is There Any Hope For Their Relationship? "IndyWatch Feed Arts"
Let me tell you a secret, everyone not all relationships are meant to last forever. There is no shame in calling it quits early on, either, if you realize your values, morals, or other preferences just dont align.
OP here is from a strict Muslim background, though he claims to be not that religious himself. He mentions that his girlfriend is American and not the modest kind, which has caused a few awkward bumps in what he describes as an otherwise smooth road.
So me (26M) and my Girlfriend (22F) have been dating for around 2 years now. Weve had our ups and downs but overall we have a great relationship, and I definitely see a future together! We really love and respect each other and connect well! But the thing is we come from different backgrounds. I come from a Muslim Background (Im not that religious tho) and she is White. However, we have still made it work and our similarities are much more than our differences.
Now my gf does like wearing a bit short clothing when out and about, which used to bother me at first and made me uncomfortable and we did have a few minor fights over it, but eventually I came to terms with it.
Recently they had a bump that he describes as a bit embarrassing, and it happened at his familys pool party.
He spoke with her ahead of time about making a modest bathing suit choice, and so was shocked to see her arrive in a cheeky bikini. OP was so mortified he couldnt look at or speak to his family!
However, recently an embarrassing situation happened. There was a pool party at my cousins house, and my parents were there too. I had recently introduced my gf to my parents as well, so this was a good time for to meet family and relatives. I specifically told her to please pack somet...
16:44
Mens begrijpen helaas niet hoe dit corrupte systeem werkt. "IndyWatch Feed Uncanny"
https://www.de-nieuwe-media.nl/l/jaap-bottenberg-gerechtsdeurwaarder-mededirecteur-en-eigenaar-van-syncasso-in-groningen-pleegde-illegale-praktijken-en-werd-een-oplichter-genoemd/ Mens begrijpen helaas niet hoe dit corrupte systeem werkt. Alles wat legaal is is per definitie niet wettig en dus fraude, valsheid in geschrifte, dwang, dwaling, afpersing, oplichting, meineed Continue Reading
Het bericht Mens begrijpen helaas niet hoe dit corrupte systeem werkt. verscheen eerst op Take care 4.
16:27
FTX debtors object to Genesis critical claims estimate of $0.00 "IndyWatch Feed Crypto"
The FTX debtors alleged that the claim was filed without any advance notice, and they were not invited to participate in the mediation.
14:57
Bedrock Upgrade: How Optimism Game-Changer Could Impact OP Price "IndyWatch Feed Crypto"
Optimism is gearing up for its eventual mainnet upgrade next week. This upgrade will offer lower protocol and security fees for users on the platform. This led to the ecosystems governance token, OP, enjoying an increase in price, albeit a modest 3.7% in the past 24 hours.
This price movement only came after last months dismal performance where OP dropped by over 30% in the monthly timeframe.
With the promise of lower fees along with Ethereum-like security for the coming upgrade, we might see OP continue its present bullishness.
Optimism: Laying The Bedrock For Future Growth
Touted as the Bedrock mainnet upgrade, it aims to improve efficiency to drive down costs for investors on the platform. According to Optimisms recent blog post, it should be able to drive protocol and security costs by a whopping 47%. The upgrade will use channels that will be split again to further optimize data compression.
Layer2 network Optimism is gearing up for the Bedrock Upgrade soon!
Discover how this game-changing update boosts scalability, security, and efficiency for Optimism, and what it means for the future of #Ethereum.#Optimism $OP #Layer2 #EIP1559
KuCoin (@kucoincom) June 2, 2023
This upgrade also corresponds to Ethereums Dencun upgrade, which will drive down on-chain costs as a result of danksharding. Danksha...
14:56
People Shared The Very Real Downsides To Being Super Attractive "IndyWatch Feed Arts"
When were young, human beings tend to think that if they could choose whether or not to be attractive, they would definitely opt in. Prettiness/Handsomeness is a type of currency and has been proven to give people a natural advantage pretty much everywhere.
That said, there are always downsides to every upside, and you can never know what its like living as someone else unless they tell you.
These pretty people have some complaints to lodge, so take a look.
That is assault.
Being groped, grabbed, etc. when youre out just trying to have fun with your friends.
I literally had a guy come up behind me at a urinal, reach around and grab my d*%k .
Thats what depression is.
Ive been told you won the genetic lottery. What do you have to be depressed about?
Mf thats what depression is. Its not about s*%t.
Complete and total.
Complete and total objectification.
It leaves you feeling as if you are never seen or even appreciated for who you are as a person, and is also why many attractive people struggle mentally.
Thats not how this works.
Im an autistic woman but, according to everyone else I cant be cuz I dont look autistic.
As if autistic people cant be pretty lol.
Pros and cons.
Background: I was never unattractive, but three years or so ago I lost 45 pounds (not on purpose horrible depressive episode) and that pushed me a lot closer to societys beauty standard.
Its also important to note that for women (and men too but to a lesser e...
14:00
Bitcoin and United States Dollar "IndyWatch Feed Crypto"
0.00010 BTC = 2.72 USD
1.00 USD = 0.00004 BTC
Converter
12:57
An Airbnb Host Noticed That Someone Stole a Painting From Her Rental and Replaced It With a Different One "IndyWatch Feed Arts"
Photo Credit: TikTok
Being an Airbnb host has to be pretty weird because you never know who youre renting your place out to
And heres another story that illustrates that point in a major way!
An Airbnb host found out that one of her guests stole one of the paintings off the wall of her rental unit and replaced it with a totally different painting.
So naturally, she shared a story about it on TikTok.
12:37
Elliptic integrates ChatGPT to bolster crypto risk detection "IndyWatch Feed Crypto"
Crypto risk management firm Elliptic believes ChatGPT will assist in scaling up intelligence and expose risks to crypto users that they cant get anywhere else.
10:58
The Lion of Chaeronea "IndyWatch Feed Literature"
Starry Night Over the Rhone, Vincent van Gogh, 1888
10:34
Whats Your Favorite Quote From South Park? Heres What People Said. "IndyWatch Feed Arts"
Its hard to believe that South Park has been on the air since FREAKING 1997.
But the show keeps chugging along and its fans have remained loyal for well over two decades.
And you and I both know that the program is chock-full of hilarious and memorable quotes, so lets check out some favorites from folks on AskReddit.
Every single time.
Eric Cartman : Alright, Token, give me a smooth bass line.
Tolkien Black : I dont know how to play bass.
Eric Cartman : Token, how many times do we have to go through this. Youre black. You can play bass.
Tolkien Black : Im getting sick of your stereotypes.
Eric Cartman : Be as sick as you want. Just gimme a goddamn bass line.
Tolkien proceeds to absolutely shred on the bass
Tolkien Black: .godda**it
That bit gets me every time.
Makes sense.
Jimmy: I lost my crutches!
Kyle: You have your crutches.
Jimmy: Its a saying among us crippled people. Wed say we lost an arm and a leg but they aint worth much.
Cartman: That makes sense.
I love life.
Butters: I love life.
Emo kids: Huh? But you just got dumped.
Butter: Yeah and Im sad.but at the same time Im really happy something can make me feel this sadits like it makes me feel alive, you know? It makes me feel human. The only way I can feel this sad now, is if I felt something really good before. So I have to take the bad with the good. So I guess what Im feeling is like a beautiful sadness.
Classy!
Im not having a glass of wine, Im having six.
Its cal...
08:09
Would You Give Into A Strangers Demands To Give Up Your Seat? "IndyWatch Feed Arts"
Social media has its downsides, but one of the good things is how much easier it is to bring awareness to things like invisible illnesses.
It has a great ability to bring home the reality that no matter what someone looks like on the outside, you never can tell what theyre dealing with behind closed doors.
OP has one of those diseases that can make getting around precarious and painful.
Alright so I (28F) have hEDS, which for those who dont know is a connective tissue disorder. One of the many symptoms is frequent injuries, especially dislocations and subluxations.
I wear ankle braces whenever I plan to be on my feet for any period of time. I also dislocated my kneecap playing with a puppy on Saturday.
They were having a particularly rough day when they got to the pharmacy, and when they were confronted by a woman who claimed she should give up her seat for older people who might want it.
I was at the pharmacy and after placing my order, sat down in the only available chair with my leg extended for my knee to get some relief.
An older woman (40s or 50s) comes up to me and says that I am young and should let the older people there have the chair.
OP snapped because they were in pain and had to deal with crap like this far too often, but when they got weird looks from others, started to wonder whether or not they went too far.
I responded by pointing at my fully visible ankle brace since my knee brace was hidden by my pants and said something along the lines Are you an idiot that thinks I wear these as a fashion statement?.
She called me a b*%ch and sulked away. The other people there gave me weird looks. Was I too harsh?
...
07:49
Warrens alleged work with short-seller shows anti-crypto army heating up "IndyWatch Feed Crypto"
Elizabeth Warren reportedly took advice from Wall Street short-seller Marc Cohodes, who cashed in on the collapse of Silvergate and Signature banks.
06:56
Musks alleged price manipulation, the Satoshi AI chatbot and more: Hodlers Digest, May 28 June 3 "IndyWatch Feed Crypto"
DOGE investor lawsuit against Elon Musk, the Satoshi Nakamoto chatbot, and the ongoing crypto debanking worldwide.
06:17
She Stuck Her Boyfriend With The Dinner Bill After He Messed Up Her Food. Is He Right To Be Mad? "IndyWatch Feed Arts"
There are way, way too many people on Reddit who are dating folks who clearly do not even like them, never mind love them.
OPs hobby is food blogging. She loves going out to try new food and new places, and posting pictures of said food on her Instagram. No big deal.
I have an Instagram account dedicated to photos and short videos of food from local restaurants in my city. I dont turn meals into a whole photoshoot production when I go out, but I like to snap a few photos of everything as it comes out.
Ive got about 1000 followers, its just a hobby for me but I have made friends with some other bloggers and we like to go out and get pics together and try new restaurants.
She usually goes out to eat with her foodie friends, because her boyfriend thinks her hobby is stupid and deliberately ruins his plate so she cant take pictures of the presentation.
I prefer doing this with my foodie girls because my boyfriend HATES it, and will go out of his way to take a big bite of food or mess up his plate with his fork before I can snap any pics, and he rolls his eyes when I take pics of my own food so I pretty much stopped bothering when we went out together.
Recently shes had some medical bills add up and so hasnt been able to enjoy as many nights out with friends. She and her boyfriend still go out infrequently, and when they do, take turns paying the bill.
She had a talk with her bf ahead of time and stated that, on the nights when she was paying, she wanted to take pictures of the appetizer and both plates, she her opportunities were limited.
Money has been tight lately...
05:18
Atomic Wallet exploited, users report loss of entire portfolios "IndyWatch Feed Crypto"
Several users have reported losses of crypto assets, claiming funds held on the Atomic Wallet app vanished.
04:52
Rapid growth in DeFi-focused Ethereum liquid staking derivatives platforms raises eyebrows "IndyWatch Feed Crypto"
Ether use in DeFi is down due to an uptick in staking, but rapid growth in LSDfi could be a bull market catalyst.
04:47
Customer Was Forced To Give Up First-Class Seat For An Airline Employee. Now What Should She Do? "IndyWatch Feed Arts"
Air travel seems like quite the risky business these days, at least from a customer service perspective. People are complaining about short tempers, a lack of cleaning protocols, the proverbial poor treatment of luggage, and a whole host of other issues.
That said, Ive never heard of a customer getting bumped from a first-class seat they paid for in order for an airline employee to sit there.
...03:09
Saturday Morning Breakfast Cereal - Grablex "IndyWatch Feed Comics"
Click here to go see the bonus panel!
Hovertext:
Slightly worried some of these are actual words.
Today's News:
02:35
02:35
Is He A Jerk For Not Wanting To Always Include His Daughters Best Friend? "IndyWatch Feed Arts"
It really stinks when you watch people you know be lazy or neglectful (or worse) parents. That goes double for when their children are besties with your children.
OPs wifes best friend has a daughter the same age as their daughter, and the girls are best friends as well. The issue is with the friends husband/father, who doesnt do anything with his daughter or pay for any activities, etc.
OP works a lot during the week and so enjoys spending lots of time with his daughter on Saturdays. For some time, though, they have always included the daughters best friend because her own parents dont have time for her.
I (31m) am married to my wife Amber (30f) we have a daughter Emma(7f) the problem is my wifes best friend Jennifer (30f) has a daughter as well Harper (7f) well Harpers dad is a lazy sack of crap and refuses to do anything with his daughter. He is the type of guy that brags about how he never changed a diaper.
Jennifer and Harper are usually at Amber and my house on the weekends because Harpers dad is drinking and watching sports all weekend. On Saturdays I normally sped all day with my daughter because I dont see her as much as i want to during the week.
However with Harper being there every Saturday anything I do with Emma I have to do with Harper. Take Emma to the zoo its Emma, Harper and I. Taught them both how to ride bikes, takes them both to dance class, take them both to the kids salon, and so on.
This came to a head when OP bought Mothers Day gifts for both kids, realizing that he was sacrificing one-on-one time with his daughter and that it was the other dad who really needed to step up.
Mothers Day was the last draw, I took them both to dance class Saturday morning ( Amber and I also pay for both dance classes because dead beet...
02:31
Brazilian crypto exchange Mercado Bitcoin licensed as payment provider: Report "IndyWatch Feed Crypto"
As a payment institution, MB Pay will enable certain digital banking services to the crypto exchanges users in the country.
01:53
Zero One Hundred Conference @ Maker Faire Rome 2023 "IndyWatch Feed Diy"
CALL FOR MAKERS OPEN UNTIL JUNE 15TH! Dedicated to all those who have a brilliant idea in mind that they would like to present. Makers, startups and companies exhibiting at this years Maker Faire Rome will have the opportunity to present their projects and plans for growth and build relations with investors at the Zero One Hundred Conference Mediterranean..
The post Zero One Hundred Conference @ Maker Faire Rome 2023 appeared first on Make: DIY Projects and Ideas for Makers.
01:18
Beskrifning om de Swenska Forsamlingars Forna och Narwarande Tilstand, uti Det sa Kallade Nya Swerige, Sedan Nya Nederland (Acrelius) "IndyWatch Feed Literature"
Beskrifning om de Swenska Forsamlingars Forna och Narwarande Tilstand, uti Det sa Kallade Nya Swerige, Sedan Nya Nederland (in Swedish; Stockholm: Harberg and Hesselberg, 1759), by Israel Acrelius (multiple formats at archive.org)
The Bread-Winners (Hay) "IndyWatch Feed Literature"
The Bread-Winners: A Social Study (New York: Harper and Bros., 1884), by John Hay (multiple formats at archive.org)
History of the Families Millingas and Millanges of Saxony and Normandy, Comprising Genealogies and Biographies of Their Posterity Surnamed Milliken, Millikin, Millikan, Millican, Milligan, Mulliken and Mullikin, A. D. 800-A. D. 1907 (Ridlon) "IndyWatch Feed Literature"
History of the Families Millingas and Millanges of Saxony and Normandy, Comprising Genealogies and Biographies of Their Posterity Surnamed Milliken, Millikin, Millikan, Millican, Milligan, Mulliken and Mullikin, A. D. 800-A. D. 1907 (Lewiston, ME: The author, 1907), by G. T. Ridlon (stable link)
A History of New Sweden (Acrelius) "IndyWatch Feed Literature"
A History of New Sweden: or, The Settlements on the River Delaware (Philadelphia: Historical Society of Pennsylvania, 1874), by Israel Acrelius, trans. by William M. Reynolds (multiple formats at archive.org)
The Introduction of Printing Into Canada (Fauteux) "IndyWatch Feed Literature"
The Introduction of Printing Into Canada: A Brief History (Montreal: Rolland Paper Co., 1930), by Aegidius Fauteux (multiple formats at archive.org)
The Money-Makers (Keenan) "IndyWatch Feed Literature"
The Money-Makers: A Social Parable (New York: D. Appleton and Co., 1885), by Henry F. Keenan (multiple formats at Google)
Lettres de Henriette-Marie de France, Reine d'Angleterre, Sa Soeur Christine, Duchesse de Savoie (Henrietta Maria) "IndyWatch Feed Literature"
Lettres de Henriette-Marie de France, Reine d'Angleterre, Sa Soeur Christine, Duchesse de Savoie (in French; Turin et al.: Bocca Frres, 1881), by Queen Henrietta Maria and Hermann Ferrero (stable link)
A Century of Loan Exhibitions, 1813-1912 (Graves) "IndyWatch Feed Literature"
A Century of Loan Exhibitions, 1813-1912 (5 volumes; London: A. Graves, 1913-1915), by Algernon Graves (page images at HathiTrust; US access only)
The First Printing in British Columbia (McMurtrie) "IndyWatch Feed Literature"
The First Printing in British Columbia (Chicago: Privately printed, 1929), by Douglas C. McMurtrie (page images at HathiTrust)
The First Printing in Manitoba (McMurtrie) "IndyWatch Feed Literature"
The First Printing in Manitoba (reprinted from the Printing Review of Canada; Chicago: Eyncourt Press, 1931), by Douglas C. McMurtrie (page images at HathiTrust)
Books, Maps and Prints Relating to New Sweden (Library of Congress) "IndyWatch Feed Literature"
Books, Maps and Prints Relating to New Sweden: Tercentenary Commemorating the First Settlement of the Swedes and the Finns on the Delaware, 1638-1938, on Exhibition at the Library of Congress, Washington, 1938 (Washington: GPO, 1938), by Library of Congress (page images at HathiTrust)
A History of New Sweden (Acrelius) "IndyWatch Feed Literature"
A History of New Sweden: or, The Settlements on the River Delaware (Philadelphia: Historical Society of Pennsylvania, 1876), by Israel Acrelius, trans. by William M. Reynolds (page images at HathiTrust)
Revolution and Counter-Revolution in Spain (Morrow) "IndyWatch Feed Literature"
Revolution and Counter-Revolution in Spain (New York: Pioneer Publishers, 1938), by Felix Morrow (page images at HathiTrust; US access only)
The Cattle Guard (Hoy) "IndyWatch Feed Literature"
The Cattle Guard: Its History and Lore (originally published 1982; open access edition Lawrence, KS: University Press of Kansas, c2021), by James F. Hoy (PDF and Epub with commentary at ku.edu)
Cemeteries and Gravemarkers (Meyer) "IndyWatch Feed Literature"
Cemeteries and Gravemarkers: Voices of American Culture (Logan, UT: Utah State University Press, 1992), ed. by Richard E. Meyer (PDF files with commentary at Project MUSE)
Catch, Release (Harun) "IndyWatch Feed Literature"
Catch, Release: Stories by Adrianne Harun (Baltimore: Johns Hopkins University Press, 2018), by Adrianne Harun (PDF files at Project MUSE)
Not Pretty, But Precious; and Other Short Stories (Hay) "IndyWatch Feed Literature"
Not Pretty, But Precious; and Other Short Stories (1872), contrib. by John Hay, Clara F. Guernsey, Margaret Hosmer, Harriet Elizabeth Prescott Spofford, Lucy Hamilton Hooper, Margret Field, Chauncey Hickox, John William De Forest, J. R. Hadermann, and R. D. Minor (Gutenberg text and illustrated HTML)
The Bread-Winners (Hay) "IndyWatch Feed Literature"
The Bread-Winners: A Social Study (New York and London: Harper and Bros., 1901), by John Hay (Gutenberg text and illustrated HTML)
Casa Pueblo (Massol Gonzlez) "IndyWatch Feed Literature"
Casa Pueblo: A Puerto Rican Model of Self-Governance (Ann Arbor: Lever Press, c2022), by Alexis Massol Gonzlez, trans. by Ashwin Ravikumar and Paul A. Schroeder Rodrguez (HTML wiht commentary at Lever Press)
The Metamorpheses (Ovid) "IndyWatch Feed Literature"
The Metamorpheses: A Complete English Translation and Mythological Index (c2000), by Ovid, trans. by A. S. Kline, illust. by Hendrik Goltzius (illustrated HTML at poetryintranslation.com)
01:02
What a DRAG! Brazilian Gay Beauty Pageant Erupts in Chaos After Losers Partner Storms Stage "IndyWatch Feed Survival"
In an absurd scene, a man charged the stage and destroyed the
winners crown at Brazils Miss Gay Mato Grosso 2023, a drag queen
beauty pageant, after his partner came in second place. #shorts
01:02
DOJ, FBI running are running a protection racket on Hunter Biden: Gregg Jarrett "IndyWatch Feed Survival"
Fox News Legal Analyst Gregg Jarrett reacts to a report that Hunter
Biden will use the Second Amendment for a legal defense for
possible possession of firearm charges, the federal probe and
discusses his new book, The Trial of the Century. #foxnews
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FOX News Channel (FNC) is a 24-hour all-encompassing news service delivering breaking news as well as political and business news. The number one network in cable, FNC has been the most-watched television news channel for 18 consecutive years. According to a 2020 Brand Keys Consumer Loyalty Engagement Index report, FOX News is the top brand in the country for morning and evening news coverage. A 2019 Suffolk University poll named FOX News as the most trusted source for television news or commentary, while a 2019 Brand Keys Emotion Engagement Analysis survey found that FOX News was the most trusted cable news brand. A 2017 Gallup/Knight Foundation survey also found that among Americans who could name an objective news source, FOX News was the top-cited outlet. Owned by FOX Corporation, FNC is available in nearly 90 million homes and dominates the cable news landscape, routinely notching the top ten programs in the genre.
Watch full episodes of your favorite shows
The Five: https://www.foxnews.com/video/shows/the-five
Special Report with Bret Baier:
https://www.foxnews.com/video/shows/special-report
Jesse Watters Primetime:
https://www.foxnews.com/video/shows/jesse-watters-primetime
Hannity: https://www.foxnews.com/video/shows/hannity
The Ingraham Angle:
https://www.foxnews.com/video/shows/ingraham-angle
Gutfeld!: https://www.foxnews.com/video/shows/gutfeld
Fox News @ Night:
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00:45
Trippy Video Shows Toddlers Reacting to an Immersive 3D Experience "IndyWatch Feed Arts"
Trippy Video Shows Toddlers Reacting to an Immersive 3D Experience
Photo: Screenshot from Reddit
Technology has allowed us to get increasingly creative with exhibits and entertainment. While 25 years ago 3D graphics only happened on computer screens, today it can be a fully developed, 360-degree experience. These kinds of works are marvelous, but our brains may still struggle to fully grasp themno matter our age. One very cute video starring a group of little kids getting up close with an interactive environment has gone viral, and we can't help but relate to them.
In the clip, the three kidsled by an avidly curious toddlertry to keep their footing as the images in the immersive space quickly shift. The scene seems to depict a rocky landscape. When the site's video first speeds up and the image lowers and moves to the side, two of the kids lose their balance despite that the floor beneath them remains perfectly still. Once up again, the littlest one tries to hold his ground as the video seems to slide at a constant speed as if he were on a moving walkway. However, once the video on the interactive screen speeds up even more, the kids take a tumble once again.
As adorable as it is to see the children react to this, the scene is a great example of how our brains process stimuli. As one Redditor explains, Your eyes mess with your balance[.] You try to take the visual information and process it before your inner ear which in this case isn't being acti...
00:02
Baseball players dont want to be political pawns: Mike Sweeny "IndyWatch Feed Survival"
Former MLB player Mike Sweeney shares his take on the Dodgers
hosting drag queen nuns on The Ingraham Angle.
Subscribe to Fox News! https://bit.ly/2vBUvAS
Watch more Fox News Video: http://video.foxnews.com
Watch Fox News Channel Live: http://www.foxnewsgo.com/
FOX News Channel (FNC) is a 24-hour all-encompassing news service delivering breaking news as well as political and business news. The number one network in cable, FNC has been the most-watched television news channel for 18 consecutive years. According to a 2020 Brand Keys Consumer Loyalty Engagement Index report, FOX News is the top brand in the country for morning and evening news coverage. A 2019 Suffolk University poll named FOX News as the most trusted source for television news or commentary, while a 2019 Brand Keys Emotion Engagement Analysis survey found that FOX News was the most trusted cable news brand. A 2017 Gallup/Knight Foundation survey also found that among Americans who could name an objective news source, FOX News was the top-cited outlet. Owned by FOX Corporation, FNC is available in nearly 90 million homes and dominates the cable news landscape, routinely notching the top ten programs in the genre.
Watch full episodes of your favorite shows
The Five: https://www.foxnews.com/video/shows/the-five
Special Report with Bret Baier:
https://www.foxnews.com/video/shows/special-report
Jesse Watters Primetime:
https://www.foxnews.com/video/shows/jesse-watters-primetime
Hannity: https://www.foxnews.com/video/shows/hannity
The Ingraham Angle:
https://www.foxnews.com/video/shows/ingraham-angle
Gutfeld!: https://www.foxnews.com/video/shows/gutfeld
Fox News @ Night:
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00:00
Nikon Z8 Review: The Best Camera for Most Serious Photographers "IndyWatch Feed Photography"
My first experience with an almost full production Nikon Z8 took me to stunning Yellowstone National Park. In the week or so that I had to play with it I found it to be a most enjoyable camera, and I was able to review most of the major aspects of the cameras handling and capabilities. However, there were still some features that I needed to test, and for that I would need to wait for a final firmware Z8.
CITD Series: Matthew James Bailey, The Promise of Artificial Intelligence "IndyWatch Feed Uncanny"
Inventing World 3.0 is a thrilling guide on how humankind can advance beyond the limitations it faces today. In a world-first disclosure and in an easy to understand narrative, this book reveals how humanity can enter into a New Golden Age with Artificial Intelligence. To be successful, a revolutionary approach to artificial intelligence is needed. This book explains how to ethically liberate this powerful ally and the incredible benefits of placing a digital intelligence within centre stage of the human story.World 3.0 is an exhilarating experience for humans. It is a time of balance and harmony, one where the digital world, society, and the environment have aligned in profound purpose and meaning. It is a Golden Age, a Singularity, founded on ethics and equity enabled by a mindset that understands the destiny of the human experiment. The digital mindset of Artificial Intelligence has been awakened to align with the purpose of our world, our nations, our cultures, and our planet. In this future, artificial intelligence has become evolutionary, operating at lightning speed within every aspect of society. It understands and honours human values and ethics. This powerful digital citizen understands the virtues that define the best of our humanity. It is a personalised digital buddy dedicated to nurture, protect and advance the wellbeing of every individual. In this world, the human experience is honoured and advanced. Pandemics and environmental catastrophes are stories of the past. Whilst being close to Utopian, this is not the ultimate destination for the human story. World 3.0 is an unbreakable foundation of awakened and ethically driven intelligences dedicated to advance humankind.Evolutionary Ethics are a breakthrough in AI and AI Ethics. Their uniqueness enables a new wave of innovation that includes all stakeholders in society. This unique perspective equips humanity to mindfully liberate Artificial Intelligence and encode an awakened digital mindset, termed Evolutionary AI. In order to create an ethical foundation for the digital world, we also uncover a new model for Data Ethics, one that guarantees the ethical quality of the digital DNA of Artificial Intelligence. Inventing World 3.0 is the playbook to liberate humankind and Artificial Intelligence into a New Golden Age. It is thought-provoking and challenges the status quo. This comprehensive guide is ideal for all leaders and citizens who wish to mindfully invent and participate in a New Tomorrow. Packed with profound insight, revolutionary models, practical guidelines, and examples, nations, communities, organisations, innovators, and citizens are equipped on how to successfully advance into a new destination for the human race.World 3.0 is a powerful human inheritance. It honours the precious gift of all forms of intelligence and life. It presents a compelling opportunity to create an unshakeable foundation to advance the human story.The book is introduced by Katalin Brtfai-Walcot...
Saturday, 03 June
23:45
Sir David Attenborough Has So Many Honors That There Are More Letters After His Name Than in It "IndyWatch Feed Arts"
Sir David Attenborough Has So Many Honors That There Are More Letters After His Name Than in It
Photo: John Cairns via Wikimedia Commons (CC BY 4.0)
Sir David Attenborough has dedicated his life to the natural world and environmental causes. His work has raised awareness of the threats that habitats face, and it reminds us how we are all connected. It's this devotion to science that has earned him multiple honors and awards. It's really awe-inspiring to see how many he has, using a unique metric to shine a light on just how many he holds. As pointed out by the Twitter account No Context Brits, Sir David Attenborough has more letters after his name than in it.
David Attenborough's name comprises 17 letters, or 20 if you want to throw the Sir distinction he earned when he was knighted by Queen Elizabeth II in 1985. After those, there are 36 more letters pertaining to the multiple orders he has been awarded and societies he's a member of. These letters are: OM, GSMG, CH, CVO, CBE, FRS, FSA, FRSA, FLS, FZS, FRSGS and FRSB.
But what do these letters mean? It's easier to first divide them among orders and societies. The former are the Order of Merit (OM), Order of St Michael and St George (GSMG), Order of the Companions of Honour (CH), the Royal Victorian Order (CVO), and Commander of the Most Excellent Order of the British Empire (CBE). These are handed out by the Royal Family for exceptional service and major contributions towards the advancement of the Arts, Learning, Literature, and Science.
The latter are fellowships that illustrate Atten...
23:23
agoodcartoon:i miss toxic men - a woman- a toxic man also... "IndyWatch Feed Comics"
i miss toxic men - a woman
- a toxic man
also credit to SCF for this stan kelly from the onion rendition
23:18
23:17
i miss toxic men - a woman- a toxic man "IndyWatch Feed Comics"
i miss toxic men - a woman
- a toxic man
23:10
The WHO Will Have Authority to Mandate Vaccines Globally "IndyWatch Feed Spiritual"
Story at-a-glance
- The 2005 International Health Regulations (IHR) is the instrument that empowers the World Health Organization to declare a Public Health Emergency of International Concern (PHEIC)
- Hundreds of amendments to the IHR are being proposed, and these amendments will empower the WHO to become the de facto governing body of all member states, including the U.S.
- As currently written, the IHR amendments will be legally binding and will supersede local and national laws. They even include enforcement tools to ensure that member nations comply with the WHOs edicts
- Areas of life that are being added in under the umbrella of health include climate, food production and even poverty, so the WHO will be able to claim sole global authority over anything to do with those issues as well
- Importantly, the IHR amendments will abolish bodily autonomy and personal choice and replace these God-given rights and freedoms with one-size-fits-all medicine
23:07
Whats The Difference Between Language And Dialect? "IndyWatch Feed Arts"
Many people might not realize that within most major languages, there are different regional dialects that exist. In most cases, experts say native speakers have no trouble navigating these slight differences, but in other cases, the alterations are stark and confusion.
That said, the latter type are still not considered their own language.
Image Credit:...
23:02
Blacks for Trump Goes Off on Ron Desantis! "IndyWatch Feed Survival"
Blacks for Trump Goes Off on Ron Desantis!
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23:02
New CA law could put these goat herders out of a job "IndyWatch Feed Survival"
Western Grazers owner Tim Arrowsmith shares how a new California
rule could wipe out goat-grazing businesses and increase wildfire
risk on Fox News Tonight.
Subscribe to Fox News! https://bit.ly/2vBUvAS
Watch more Fox News Video: http://video.foxnews.com
Watch Fox News Channel Live: http://www.foxnewsgo.com/
FOX News Channel (FNC) is a 24-hour all-encompassing news service delivering breaking news as well as political and business news. The number one network in cable, FNC has been the most-watched television news channel for 18 consecutive years. According to a 2020 Brand Keys Consumer Loyalty Engagement Index report, FOX News is the top brand in the country for morning and evening news coverage. A 2019 Suffolk University poll named FOX News as the most trusted source for television news or commentary, while a 2019 Brand Keys Emotion Engagement Analysis survey found that FOX News was the most trusted cable news brand. A 2017 Gallup/Knight Foundation survey also found that among Americans who could name an objective news source, FOX News was the top-cited outlet. Owned by FOX Corporation, FNC is available in nearly 90 million homes and dominates the cable news landscape, routinely notching the top ten programs in the genre.
Watch full episodes of your favorite shows
The Five: https://www.foxnews.com/video/shows/the-five
Special Report with Bret Baier:
https://www.foxnews.com/video/shows/special-report
Jesse Watters Primetime:
https://www.foxnews.com/video/shows/jesse-watters-primetime
Hannity: https://www.foxnews.com/video/shows/hannity
The Ingraham Angle:
https://www.foxnews.com/video/shows/ingraham-angle
Gutfeld!: https://www.foxnews.com/video/shows/gutfeld
Fox News @ Night:
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23:01
Is Bidens controversial Bitcoin mining tax dead or set to rise from the ashes? "IndyWatch Feed Crypto"
References to the tax were removed from the U.S. debt bill, but that doesnt mean its gone for good.
22:59
Quant Hype Spikes As Price Surges 15% Is This A Top Signal? "IndyWatch Feed Crypto"
Quant (QNT), an Ethereum-based token, has experienced a 15.15% increase in its price over the past seven days. QNT plays a vital role in Quant Networks Overledger, a suite of enterprise software solutions designed to connect public blockchains and private networks seamlessly. By enabling the creation of multi-chain decentralized applications (mDapps), Quant Network empowers developers to build and operate applications that span across multiple blockchains simultaneously.
With its focus on interoperability, Quant Networks Overledger solution provides a framework for bridging different blockchain networks, fostering connectivity and facilitating efficient data exchange between disparate systems. The use of QNT within the Overledger ecosystem not only powers these interoperability capabilities but also plays a crucial role in securing and incentivizing participants within the network.
As the price of Quant (QNT) continues its upward trajectory, the growing interest in the token reflects the recognition of its importance in enabling the seamless operation of mDapps and facilitating cross-chain communication. With Quant Networks innovative approach to interoperability, the future holds promising possibilities for enhanced collaboration and integration across various blockchain platforms.
Related Reading: Injective Protocol (INJ) Tallies 23% Price Surge In Past 7 Days Heres Why
Whys There A Strong Bullish Sentiment For QNT?
The recent price surge of Quant (QNT) can be attributed to the transformative power of distributed ledger technology (DLT) and the unique features offered by the Quant platform. DLT, surpassing the limitations of traditional blockchain, provides solutions to unanswered questions, enabling secure and cost-effective asset exchange while driving value, opening new markets, and increasing efficiency for enterprises, governments, and individuals worldwide.
...22:46
People Share Their Ideas On What To Say If Someone Asks Whats Your Problem? "IndyWatch Feed Arts"
Listen, we all have problems. Some of us have earned them and others seem to find them on accident, but they just make us human, right?
You might think people are genuinely asking about your life when they pose this question but theyre probably not and if theyre going to ask a sassy question, you need a sassy answer at the ready.
People are the problem.
Well In the beginning the Universe was created. This has made a lot of people very angry and been widely regarded as a bad move.
The hardest part.
Oh boy. Where to start.
An inside joke.
With my family, its usually predicated with what the f**k is wrong with you?!. The usual response isI kill people and eat hands, thats two things.
For the record, its a reference to Llamas With Hats that we all know.
Because that will take even longer.
you want them alphabetical or what?
Never enough.
Cookies. There is never enough.
This confuses the foe. Optionally you can also start stripping. That might scare them enough to back off.
Alternatively they might mistake that for an invitation and Surprise butt s^x. Depends on your taste that might be right up your alley.
Just go for confusion.
The story doesnt m...
22:42
Is She Wrong for Letting Her Older Brother and His Kids Be Homeless? People Responded. "IndyWatch Feed Arts"
Hey, you cant help everyone, right?
And the kinds of situations where you cant or wont help out family members can be particularly touchy
So is this woman an a**hole for what she DIDNT do to help out her older siblings?
Check out her story below and see what you think.
AITA for never helping my older siblings out and letting my brother and his kids be homeless?
My family is on a big divide about this so I was hoping I could get an unbiased perspective. I am the youngest of four siblings, by far. I am 22F and my husband is 26M.
My siblings are 30F, 32M, 33M. Between the three of them they have a combined 14 children. They all have multiple children. None of them went to college, and they all work lower paying entry level jobs. I graduated last year (I started college in high school) and I work as a nurse.
My husband works on planes but I dont want to say what he does specifically. Our household income is about 200k, and average where we live is about 80k I think. This is all relevant.
My parents like to host big family functions for every holiday and they bring the whole family together. Ever since I was a teenage my siblings have always asked me for favors, mostly to babysit. I did it for a while when I was around 16, but quickly realized they didnt appreciate anything and there was nothing in it for me so I stopped.
For the past 6 years Ive had the dont ask me for anything stance, since my sibl...
22:36
XRP Climbs 12% As Crypto Celebrates 11-Year Milestone "IndyWatch Feed Crypto"
XRP is now marking its 11th year since its inception. Over the past decade, XRP has established itself as a prominent player in the blockchain industry, captivating the attention of investors and enthusiasts alike.
With its all-time performance reaching remarkable heights, the crypto continues to demonstrate its resilience and enduring value in the ever-evolving landscape of digital finance.
As it enters the next chapter of its journey, the crypto continues to attract attention and generate excitement among both long-time supporters and newcomers to the world of cryptocurrency.
XRP is 11 years old today the cryptocurrency was born on June 2, 2012. pic.twitter.com/l6ue4GcpZd
Sjuul | AltCryptoGems (@AltCryptoGems) June 2, 2023
Price Surge And Resilience
At the time of writing, the price of XRP on CoinMarketCap currently stands at $0.523. This figure highlights a slight increase of 1.4% within the past 24 hours, and a decent climb of 11% over the course of seven days. These figures are indicative of the significant growth it has experienced in recent times, with a staggering 8,679.89% increase since its initial introduction to the market.
Ahead of this 11th-year milestone, Ripple, the company behind XRP, took a strategic step by locking 700 million of the tokens into a series of escrows.
This initiative aligns with Ripples ongoing commitment to effectively manage the supply and distribution of XRP. The introduction of the escrow mechanism serves as a mechanism to ensure a controlled and predictable release of tokens into the market.
By implementing these escrows, Ripple aims to provide stability and transparency to XRPs market dynamics. This strategic...
22:02
Over 50? Make Sure to Have This Daily! "IndyWatch Feed Survival"
In this informative video, we delve into the importance of
nutrition for overall well-being, especially after 50 years old.
Learn about the dietary changes that occur with age and how foods
rich in vitamins and antioxidants can help you maintain energy,
calm, and balance.
We also tackle a prevalent issue among older adults falls and injuries. Shocking statistics reveal the impact of these accidents, including fractures and intracranial injuries, with hip fractures posing a significant risk to morbidity and mortality post-fall. But fret not! If youre over 50, we reveal a delicious and beneficial vegetable that deserves a prominent spot in your diet.
Not only are these vegetables incredibly nutritious, but they also contribute to maintaining a healthy weight due to their low calorie and carbohydrate content. Furthermore, their fiber content aids in promoting digestive and intestinal health.
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Disclaimer: The materials and the information contained on Natural
Cures channel are provided for general and educational purposes
only and do not constitute any legal, medical or other professional
advice on any subject matter. These statements have not been
evaluated by the FDA and are not intended to diagnose, treat or
cure any disease. Always seek the advice of your physician or other
qualified health provider prior to starting any new diet or
treatment and with any questions you may have regarding a medical
condition. If you have or suspect that you have a medical problem,
promptly contact your health care provider.
#naturalcures #homeremedies
22:02
MASSIVE NON-COMPLIANCE: How Many Registered Their Pistol Braced Firearms With ATF?!? "IndyWatch Feed Survival"
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The opinions expressed through this video are the opinions of the individual author and are for educational and documentary purposes only.
FAIR USE: In the rare instance I include someone elses footage it is covered in Fair Use for Documentary and Educational purposes with the intention of driving commentary and allowing freedom of speech.</p> <p>IMPORTANT: All shooting is done on state-approved firing ranges by trained professionals. Our videos are produced in a safe environment by highly trained professionals with decades of experience. These videos are strictly for educational and entertainment purposes only. Imitation or the use of anything demonstrated in my videos is done AT YOUR OWN RISK. Do not attempt to replicate the actions featured in our videos without the proper training, licensing, and medical professionals present.</p> <p>We are not attempting to sell you the items featured in this video. We are not instructing our viewers on how to modify firearms, accessories, or otherwise change their basic legal function. All firearms and accessories are legal products commonly available in stores all across the United States. Our videos are for entertainment purposes only. We are not a gun shop and...</p>
22:02
Friday Follies: The great DeSantis name debate "IndyWatch Feed Survival"
Unruly passenger disrupts flight Gen-Zs sex recession and
octogenarian fathers Lisa Kennedy Montgomery and Raymond Arroyo
have it all on The Ingraham Angle Friday Follies.
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Watch more Fox News Video: http://video.foxnews.com
Watch Fox News Channel Live: http://www.foxnewsgo.com/
FOX News Channel (FNC) is a 24-hour all-encompassing news service delivering breaking news as well as political and business news. The number one network in cable, FNC has been the most-watched television news channel for 18 consecutive years. According to a 2020 Brand Keys Consumer Loyalty Engagement Index report, FOX News is the top brand in the country for morning and evening news coverage. A 2019 Suffolk University poll named FOX News as the most trusted source for television news or commentary, while a 2019 Brand Keys Emotion Engagement Analysis survey found that FOX News was the most trusted cable news brand. A 2017 Gallup/Knight Foundation survey also found that among Americans who could name an objective news source, FOX News was the top-cited outlet. Owned by FOX Corporation, FNC is available in nearly 90 million homes and dominates the cable news landscape, routinely notching the top ten programs in the genre.
Watch full episodes of your favorite shows
The Five: https://www.foxnews.com/video/shows/the-five
Special Report with Bret Baier:
https://www.foxnews.com/video/shows/special-report
Jesse Watters Primetime:
https://www.foxnews.com/video/shows/jesse-watters-primetime
Hannity: https://www.foxnews.com/video/shows/hannity
The Ingraham Angle:
https://www.foxnews.com/video/shows/ingraham-angle
Gutfeld!: https://www.foxnews.com/video/shows/gutfeld
Fox News @ Night:
https://www.foxnews.com/video/shows/fox-news-night
Follow Fox News on Facebook:
https://www.facebook.com/FoxNews/
Follow Fox News on Twitter: https://twitter.com/FoxNews/
Follow Fox News on Instagram:
https://www.instagram.com/foxnews/
22:00
Trumps Persistent Election Result Denials Demonstrate The Need For Bitcoin-Verified Truth "IndyWatch Feed Crypto"
This is an opinion editorial by Dan Weintraub, an author and high school teacher who first became interested in Bitcoin while teaching economics.
I recently watched with bemused indifference CNNs Donald Trump town hall charade, yet another in an endless list of macabre political and social zombie dances.
The truth is, I dont care all that much anymore about party politics, about the upcoming presidential election cycle, about supposedly heartfelt and earnest liberal and conservative political expressions within the American polity, about the hand-wringing surrounding the tenuous future of American Democracy, etc. What I do care about, however, is how easy it is for human beings to be manipulated, to believe the lies.
We are all sheep blind followers with little sense of discernment we are all entirely programmable and entirely impressionable. History may not repeat itself per se, but as an endless record of follower-humans following leader-humans off of proverbial cliffs demonstrates (and for no other reason than the leader-humans were/are really skilled at lying), it certainly feels like dj vu all over again.
Worry not! This is not an article about Trump or about ideological disaffection. Trump is just one man in a human melodrama that spans millennia. The focus of this piece is about the role Bitcoin can play in restoring belief and in ending human somnambulance; it is about how we disempower the disinformationalists. And it is a warning, for those in power will go to any lengths to maintain their hypnotic grip on humanity.
Why Governments Fear Bitcoin
So, the first question we must examine is this: Why are governments seemingly so afraid of Bitcoin? Interestingly, its not simply because Bitcoin has the potential to end governments monopoly on money (which is admittedly a pretty big deal in and of itself). No. The underlying reason actually indicates something far more fundamental: Governments are afraid of Bitcoin as a construct because governments can only govern through deceit and dishonesty.
You see, the most powerful and successful governments throughout history have been (and remain) the ones that are the most adroit and accomplished at lying. The United States government, that bastion of supposed democratic righteousness, is in fact a compelling example of this principle. From Vietnam to Iraq, Joseph McCarthy to Lyndon Johnson to Jerome Powell and beyond, U.S. history is replete with examples of the power of lies, and of the malleability of the minds of well-intentioned, patriotic, innocent, hopeful, lost citizens.
Bitcoin Outs The Lies
Back to Trump for a moment. This from the BBC:
Mr. Trump has questioned the legitimacy...
21:31
The Lion of Chaeronea "IndyWatch Feed Literature"
The Israelites Leaving Egypt, David Roberts, 1828 or 1830
21:24
Totally crazy: This is the worlds first camera without lens that creates AI generated images based on your location! "IndyWatch Feed Photography"
Danish artist Bjoern Karmann created this stunning new invention: A camera without lens that creates images using AI tech! This is how it works: Introducing Paragraphica! A camera that takes photos using location data. It describes the place you are at and then converts it into an AI-generated "photo". See more here: https://t.co/Oh2BZuhRcfor try
The post Totally crazy: This is the worlds first camera without lens that creates AI generated images based on your location! appeared first on mirrorlessrumors.
21:02
OpenAI commits $1M to support AI-driven cybersecurity initiatives "IndyWatch Feed Crypto"
As criminals devise innovative ways to exploit AI for malicious intentions, OpenAI remains committed to equipping defenders with the necessary tools.
21:01
Joey Jones: Is President Biden fit to serve? "IndyWatch Feed Survival"
Fox News contributor Johnny Joey Jones asks if President Biden is
really as sharp as he claims to be in the opening monologue of Fox
News Tonight.
Subscribe to Fox News! https://bit.ly/2vBUvAS
Watch more Fox News Video: http://video.foxnews.com
Watch Fox News Channel Live: http://www.foxnewsgo.com/
FOX News Channel (FNC) is a 24-hour all-encompassing news service delivering breaking news as well as political and business news. The number one network in cable, FNC has been the most-watched television news channel for 18 consecutive years. According to a 2020 Brand Keys Consumer Loyalty Engagement Index report, FOX News is the top brand in the country for morning and evening news coverage. A 2019 Suffolk University poll named FOX News as the most trusted source for television news or commentary, while a 2019 Brand Keys Emotion Engagement Analysis survey found that FOX News was the most trusted cable news brand. A 2017 Gallup/Knight Foundation survey also found that among Americans who could name an objective news source, FOX News was the top-cited outlet. Owned by FOX Corporation, FNC is available in nearly 90 million homes and dominates the cable news landscape, routinely notching the top ten programs in the genre.
Watch full episodes of your favorite shows
The Five: https://www.foxnews.com/video/shows/the-five
Special Report with Bret Baier:
https://www.foxnews.com/video/shows/special-report
Jesse Watters Primetime:
https://www.foxnews.com/video/shows/jesse-watters-primetime
Hannity: https://www.foxnews.com/video/shows/hannity
The Ingraham Angle:
https://www.foxnews.com/video/shows/ingraham-angle
Gutfeld!: https://www.foxnews.com/video/shows/gutfeld
Fox News @ Night:
https://www.foxnews.com/video/shows/fox-news-night
Follow Fox News on Facebook:
https://www.facebook.com/FoxNews/
Follow Fox News on Twitter: https://twitter.com/FoxNews/
Follow Fox News on Instagram:
https://www.instagram.com/foxnews/
21:00
Weekend reads: How university rankings lead to bad science; how to report research misconduct; the impact of Retraction Watch reporting "IndyWatch Feed Health"
Would you consider a donation to support Weekend Reads, and our daily work?
The week at Retraction Watch featured:
- Exclusive: Alleged research misconduct cost Turkish surgeons tenure
- Scientist with six retractions wins challenge of firing, funding ban
- In the Death of an Iranian Scientist, Hints of Unchecked Strife
Our list of retracted or withdrawn COVID-19 papers is up to more than 300. There are now 40,000 retractions in our database which powers retraction alerts in EndNote, LibKey, Papers, and Zotero. The Retraction Watch Hijacked Journal Checker now contains 200 titles. And have you seen our leaderboard of ...
20:45
Whales ARB Accumulation Rekindles Momentum For DeFi Token Heres Why "IndyWatch Feed Crypto"
Arbitrum (ARB), a prominent governance token in the decentralized finance (DeFi) ecosystem, recently witnessed a decent surge in price following renewed buying activity from a well-known DeFi whale address.
Large-scale investors often influence market sentiment and can significantly impact the price of a given asset. However, as the rally unfolds, questions arise about the sustainability of this upward momentum and its implications for the future of Arbitrum.
Whales Unusual Buying Activity Coincides With ARBs Rally
Arbitrums (ARB) current price of $1.24 on CoinMarketCap highlights its remarkable performance, with a noteworthy 3.4% rally witnessed within the past 24 hours, followed by an impressive seven-day climb of 7%. Interestingly, this surge in value coincided with unusual buying activity associated with renowned trader Andrew Kangs crypto addresses.
Particularly noteworthy is the fact that Andrew Kang, co-founder of Mechanism Capital, has been making some interesting movements within the Arbitrum ecosystem.
Kang put $1 million worth of stablecoins into Arbitrum pools and allocated nearly a quarter of the funds to the purchase of RDNT tokens. RDNT is the native token of the DeFi lending platform Radiant Capital.
After filling his bags with RDNT, Kang subsequently exchanged his newly acquired tokens and existing RDNT reserves for $867,000 worth of ARB.
These transactions were further followed by Kang depositing the proceeds into Radiant Capital, where he borrowed Circles USD Coin. These details have been revealed through data obtained from Lookonchain, a reliable data resource.
Seems like Andrew Kang is using leverage to go long $ARB on @RDNTCa...
20:45
Injective Protocol (INJ) Tallies 23% Price Surge In Past 7 Days Heres Why "IndyWatch Feed Crypto"
Injective Protocol, a prominent blockchain platform catering to decentralized applications (dApps), has recently gained significant attention due to the notable surge in the price of its native token, injective (INJ). Over the past week, the INJ token has experienced a remarkable growth rate of 23%.
This surge reflects the growing market interest in the platform and underscores the utility and governance features associated with the INJ token. Serving as a dual-purpose instrument, the INJ token empowers users by offering them utility within the platform while granting them a say in shaping its future through governance mechanisms.
Whats The Cause Of The Spike?
At the time of writing, the price of INJ stands at $7.83, experiencing a minor 0.9% decline within the day. However, over the course of the week, INJ has demonstrated a commendable increase of 23%. This surge in price is coupled with a circulating supply of $100 million, contributing to the platforms liquidity and overall market dynamics. The positive market sentiment and a high Total Value Locked (TVL) have been identified as key factors driving the recent price boom for Injective (INJ).
Related Reading: Celsius Sets New Standard: $1 Billion In ETH Staked As Deposits Show No Sign Of Slowing
Exciting developments lie ahead for Injective as it reveals its plans to revamp its proof-of-stake (PoS) delegation mechanism through the Avalon upgrade. This upgrade will introduce an advanced system, incorporating sub-second block times and layer-1 scalability optimizations. By leveraging the Avalon upgrade, Injective (INJ) aims to enhance transaction speed and efficiency, promising a more seamless user experience on the platform.
The impressive growth of Injective (INJ) and its commitment to innovation through the Avalon upgrade position the project as a notable player in the blockchain industry. With a positive market outlook and advancements on the horizon, Injective (INJ) continues to captivate inve...
20:44
When Your Own Government CONFIRMS It Paid Censors to Silence You "IndyWatch Feed Survival"
Author of What to Eat When Youre Broke and Bloom Where Youre Planted online course
If youve been around for very long, you know this website has suffered repeated hits for our content. Weve been defunded, weve been hit by algorithmic changes that make it harder for people to find us, and weve been classified as a disinformation site. All of this has happened despite the fact we offer factual coverage and often use mainstream sources that are not targeted by censors.
While Ive had my suspicions since the attacks first began, imagine the sick feeling in the pit of my stomach when I recently read an expose by the Washington Examiner in which the United States government readily admitted giving funding to the very business that abruptly defunded my website back in 2021.
The US State Department stands by grant to fund censorship
Its hard to believe that Im writing this about the government of the United States of America, but here we are in 2023 with our own government striving to make at least half the country out to be terrorists and second-class citizens. An exclusive report by the Washington Examiner states:
The State Department stands by its widely scrutinized grant to a group the Washington Examiner revealed is blacklisting conservative media outlets, according to a letter to Congress.
Rep. Darrell Issa (R-CA)...
20:01
Sen. Ted Cruzs push to save AM radio: This is an enormous problem | Fox News Rundown "IndyWatch Feed Survival"
After several automakers announced plans to remove AM radios from
electric cars moving forward, Senator Ted Cruz (R-TX) sprung into
action to introduce legislation to save consumers ability to tune
into AM stations. Working alongside Senator Ed Markey (D-MA),
Senator Cruz created the AM for Every Vehicle Act, which has gained
popular bipartisan support in Congress. Senator Cruz joins the
podcast to share how AM radio remains an important tool for
communicating during emergencies and his suspicion that the push to
end AM radio was targeting conservative voices. Later, he explains
how Democrats excessive spending led to the national debt growing
out of control. #foxnews
Subscribe to Fox News! https://bit.ly/2vBUvAS
Watch more Fox News Video: http://video.foxnews.com
Watch Fox News Channel Live: http://www.foxnewsgo.com/
FOX News Channel (FNC) is a 24-hour all-encompassing news service delivering breaking news as well as political and business news. The number one network in cable, FNC has been the most-watched television news channel for 18 consecutive years. According to a 2020 Brand Keys Consumer Loyalty Engagement Index report, FOX News is the top brand in the country for morning and evening news coverage. A 2019 Suffolk University poll named FOX News as the most trusted source for television news or commentary, while a 2019 Brand Keys Emotion Engagement Analysis survey found that FOX News was the most trusted cable news brand. A 2017 Gallup/Knight Foundation survey also found that among Americans who could name an objective news source, FOX News was the top-cited outlet. Owned by FOX Corporation, FNC is available in nearly 90 million homes and dominates the cable news landscape, routinely notching the top ten programs in the genre.
Watch full episodes of your favorite shows
The Five: https://www.foxnews.com/video/shows/the-five
Special Report with Bret Baier:
https://www.foxnews.com/video/shows/special-report
Jesse Watters Primetime:
https://www.foxnews.com/video/shows/jesse-watters-primetime
Hannity: https://www.foxnews.com/video/shows/hannity
The Ingraham Angle:
https://www.foxnews.com/video/shows/ingraham-angle
Gutfeld!: https://www.foxnews.com/video/shows/gutfeld
Fox News @ Night:
https://www.foxnews.com/video/shows/fox-news-night
Follow Fox News on Facebook:
https://www.facebook.com/FoxNews/
Follow Fox News on Twitter: https://twitter.com/FoxNews/
Follow Fox News on Instagram:
https://www.instagram.com/foxnews/
20:00
Supersoldiers and Ascended Masters Two Pathways for Humanitys Emergence into Galactic Society "IndyWatch Feed Spiritual"
Over the last two decades, multiple individuals have come forward to reveal their recruitment and training as supersoldiers used in secret space programs, and for armed encounters with extraterrestrial entities. The use of supersoldiers goes back centuries. The governing elites struck secret deals to have a cadre of specially trained soldiers ready to battle either []
20:00
Cochranes Demise: Misleading Denigration of Benzodiazepines for Acute Psychosis "IndyWatch Feed Health"
The Cochrane Collaboration was once one of the most trusted institutions in healthcare. People trusted Cochrane systematic reviews, even those of psychiatric drugs. However, in 2018, a highly skilled researcher in Cochrane, Professor Tom Jefferson, said in an interview in the article, Cochrane a sinking ship?: If your review is made up of studies which are biased and in some cases are ghost written or the studies are cherry picked and you dont take that into account in your review, then its garbage in and garbage out with a nice little Cochrane logo on it.
About the failing scientific integrity of Cochrane reviews, Cochranes major funder announced in 2019 that, This is a point raised by people in the Collaboration to ensure that garbage does not go into the reviews; otherwise, your reviews will be garbage. Four months later, the funder announced that their funding of Cochrane review groups based in the UK would cease at the end of March 2023. I have described these issues in my freely available book, The Decline and Fall of the Cochrane Empire.
Today, most of the UK based Cochrane review groups have closed. Many see this as the beginning to the end for a Cochrane that cared too little about scientific rigour and too much about protecting guild interests and other financial interests, and which had become too close to industry.
As I have demonstrated in my books and articles, almost all Cochrane reviews of psychiatric drugs are garbage-in, garbage-out. This, I confirmed in the newest Cochrane meta-analysis of depression pills in child...
19:47
Women Stuns Her Boyfriend By Learning To Speak Greek. His Reaction Is Adorable. "IndyWatch Feed Arts"
Photo Credit: TikTok
Relationships are hard, and if were being honest, theres not a lot of positive talk around the internet these days when it comes to love and whether or not it can last.
Thats why videos like this one are so uplifting the genuine happiness people are able to bring to each other when they put in some effort is always a good reminder.
Photo Credit: TikTok
In it, Kate (@kateplus8ft) surprises h...
19:47
Remote Viewer saw an Extraterrestrial base buried around Mt. Hayes, Alaska "IndyWatch Feed Spiritual"
18:42
Floki Inu Gains Momentum As Chinese E-Commerce Giant Recognizes Its Utility "IndyWatch Feed Crypto"
Floki Inu (FLOKI) is taking a giant leap forward in the world of meme assets. In an exciting development, the team behind this dog-themed cryptocurrency has unveiled a groundbreaking announcement: users can now utilize Floki to make purchases on AliExpress, a global e-commerce giant.
This unprecedented integration with one of the worlds largest online retailers is set to revolutionize the way people perceive and interact with cryptocurrencies, catapulting Floki Inu to new heights of recognition and utility.
Floki Inu: Revolutionizing E-Commerce With AliExpress Integration
In an announcement, FLOKI holders can now harness the power of their digital assets to make seamless purchases on AliExpress.
AliExpress is a Chinese-based online retail service operated by the Alibaba Group. It was established in 2010 and is comprised of small businesses in China and other locations, such as Singapore, that sell products to international online shoppers.
You can now purchase products on #AliExpress using $FLOKI through https://t.co/ee0PBRn2Nh!
Buy from a selection of over 100 million items and enjoy shipping to over 200 countries.#FLOKIs ecosystem keeps growing!
https://t.co/XEeOLamoQ9
FLOKI (@RealFlokiInu) May 31, 2023
This milestone has been made possible through the integration of Shopping.io, a crypto-focused e-commerce protocol that opens doors for shoppers to utilize various digital currencies for transactions with major retailers.
Among its extensive list of partner platforms are retail giants such as Walmart, Amazon, eBay, and Etsy, offering an unparalleled shopping experience powered by cryptocurrencies.
Shopping.io serves as a bridge between the realm of cryptocurrencies and mainstream e-commerce, revolutionizing the way digital assets are perceived and utilized in everyday transactions.
By seamlessly integrating with popular online marketplaces, this crypto-focused e-commerce pro...
18:36
Uniswap scam alert: Fraudsters impersonate executives and create fake website "IndyWatch Feed Crypto"
Uniswap and its foundation have no association with the scam as efforts are being made to combat it.
17:28
Nieuwsbrief 8 staat klaar "IndyWatch Feed Uncanny"
Beste leden..Nieuwsbrief 8 staat klaar om verzonden te worden .Deze is voor de witwasmachine de BELASTINGDIENST.Voor iedereen wat een afwijzing heeft met de anbi hebben we nu in heerlen 1 Continue Reading
Het bericht Nieuwsbrief 8 staat klaar verscheen eerst op Take care 4.
17:25
Welcome To Craft Schooling Sunday! "IndyWatch Feed Craft"
And so it goes, running late with the features, so please share your latest in the mean time, and thanks for stopping by! You are invited to the Inlinkz link party! Click here to enter
17:15
More Big Tech Woes: LCD Soundsystem Announces Round of Layoffs "IndyWatch Feed Satire"
NEW YORK VC startup and indie music factory LCD Soundsystem announced their first-ever round of layoffs affecting all organizational units effective immediately, worried economists report.
I regret to announce that today is a difficult one for our organization; LCD Soundsystem, Incorporated is losing its edge and must lay off 34% of our workforce, said frontman and CEO James Murphy in a company-wide email. I offer my deepest gratitude to everyone affected for their years of service. But market forces dictate that we must tighten the belt if we hope to produce another Sound of Silver down the line or have Daft Punk ever play at my house again.
Seniority did not seem to be a major factor in deciding which departments and employees would suffer the cuts.
I was just two years away from a pension and Im devastated, uttered a crestfallen Nancy Whang, one of the longest-tenured employees at LCD Soundsystem. I was brought into the conference room where James gave me the news in an obviously prepared 30-second speech, then he rushed out and left me with our head of HR. He couldnt make eye contact with me; what a coward. They gave me one little cardboard box to pack up all my synths from my desk. I could barely fit my MicroKORG in it, let alone all my other keyboards. Ive sent my resume to Gorillaz and St. Vincent, but maybe I should start my own solo company? Ive been dreaming of going the entrepreneur route for years.
Economists warn that the contagion of layoffs could continue to spread to other indie music institutions.
We dont expect the trend to reverse anytime soon; rumor has it Interpol released their in-house suit tailor today, said Alvin Bingham, host of Indie Band Report on CNBC. Jack White laid off his entire haberdashery staff last week, and The Mountain Goats have decided to outsource their research department. But we have found a few exceptions- Kraftwerk is hiring renewable energy engineers, and Mac Demarco needs a new weed guy. So there are still some jobs out there.
A leak from within LCD Soundsystem, Incorporated confirmed that Murphys layoff email used the subject line Inflation, I Love You But Youre Bringing Me Down.
The post More Big Tech Woes: LCD Soundsystem Announces Round of Layoffs appeared first on The Hard Times.
17:13
Every Joyce Manor Album Ranked "IndyWatch Feed Satire"
Joyce Manor doesnt have any bad albums, but its important to know which ones are the best so you can prioritize those on your smoke break. Listening to all of them was pretty easy. Their entire discography is the length of one long movie or two short ones. Here is our definitive ranking of all 6 Joyce Manor studio albums from good to great.
6. Of All Things I Will Soon Grow Tired (2012)
Sophomore albums are always difficult to pull off.
Joyce Manor couldve been the exception to that rule had our
fact-checkers not reminded us that Never Hungover Again was
actually their third album. We didnt forget about this one entirely
its just hard to remember that this is a canonical Joyce Manor
album and not just a 13-minute compilation of promising demos. For
what its worth, there are some great tracks here. They just dont
feel like theyre part of anything bigger than themselves. Even
Napalm Death songs make better use of their brief runtimes.
Play it again: Violent Inside
Skip it: Youd be forgiven.
Honorable Mention: Songs From Northern Torrance (2020)
Now this is a great compilation of promising demos.
Featuring rough drafts of fan favorites like Constant Nothing and
Leather Jacket alongside fast-paced punk tracks that would have
felt out of place on a proper studio album, its an insightful look
into the bands early years. Every track radiates charmingly chaotic
energy, from frenetic acoustic opener House Warning Party to the
freshly remastered Constant Nothing EP songs that close this out.
Most importantly, it reminds fans that Joyce Manor formed in
Torrance, California, so you can gently correct anyone who calls
them midwest emo.
Play it again:...
17:05
Straight Edge Guy at Bachelor Party Spends Entire Time Trying to Convince Stripper to Go Vegan "IndyWatch Feed Satire"
LAS VEGAS Lifelong straight edger Logan McGuire spent the majority of his future brother-in-laws bachelor party convincing the stripper to go vegan, despite being surrounded by endless debauchery, confirmed multiple tanked groomsmen.
I dont know how anyone in this strip club can think about naked women when hundreds of thousands of cows are being brutally slaughtered every day, their blood is greasing the gears of capitalism. My sisters fiance didnt want to hear about it anymore, but the dancer at our table was surprisingly attentive and its been a while since Ive been able to talk about the benefits of veganism without someone walking away mid-conversation, said McGuire. It cost me $200 to get my entire point across about how dairy cows are tortured on a daily basis, but I bet when she goes home tonight shell switch to soy milk.
The dancer at the bachelor partys booth noted that McGuire was the first client she ever met who paid her to not do her job.
Ive met a lot of gross dudes whove paid me to do weird shit, so this was a nice reprieve. Usually when men want to just talk they complain about their wives, but Logan was the first one to show me data about how factory farming is exacerbating climate change. I have to salute his commitment to explaining the evils of the farming industrial complex with my tits in his face, said Candy Jones. The other guys in his party were getting kind of annoyed, but honestly he was shelling out the most cash. I wouldve offered him a private dance but he refused. I think he was Mormon or something.
McGuires soon-to-be brother-in-law was hoping for a more traditional stag party without any politics.
I cant wait to marry his sister, but I cannot wait even more to only see this guy on holidays. My best man really went out of his way to curate a neverending cavalcade of pussy and beer for three days straight, and Logan kept knocking the drinks out of our hands any time we walked by him. Im trying to get this stripper to sit on my face but he keeps sidetracking her about how overfishing is destroying delicate ocean ecosystems, said Bill Lawrey. None of the other dancers will even come near us now. I cant imagine the rant hell go on when I tell him were going out for cigars and steaks after this.
As of press time, the party was asked to leave the club after McGuire insisted on giving Candy a copy of Earth Crisis Destroy the Machines.
The post Straight Edge Guy at Bachelor Party Spends Entire Time Trying to Convince Stripper to Go Vegan appeared first on The Hard Times.
17:05
Heartwarming: This Second Grader Dreams of One Day Becoming President Despite Being Named Tristan "IndyWatch Feed Satire"
If youre looking for a feel-good story about overcoming adversity, weve got the perfect one for you today out of Indianapolis, where local second grader, Tristan Fuller has announced his intention to one day become President of the United States, despite the fact that his name is literally Tristan.
According to his classmates and teacher, the plucky, if utterly deluded, eight-year-old came to school for his presentation on what I want to be when I grow up in a full suit and tie, and announced his future candidacy for the highest office in the land, as if theres a future in which someone named Tristan would hold the nuclear codes.
This isnt to say that Fuller isnt a precocious and civically minded boy. When I had the chance to sit down with him, he was all too happy to list some of the policies he would enact, such as: Shorter school days, less homework, and longer summers.
Hes got our vote! I mean, not literally, his name is fucking Tristan for chrissakes, but you know what we mean.
While childish, these policies show a clear focus on enacting change. Its just too bad that when one thinks of the name Tristan, one can only see a future to be a future of skinny jeans, bass guitars, bad tattoos, and a semi-serious nicotine addiction.
Many community members have voiced their anxieties about Tristans goal of Presidency, suggesting that a career selling weed outside the local movie theater might be just as rewarding and more within his grasp. Historically, American presidents have been named things like John, Abraham, and George. But Tristan wont let any naysayers dissuade him. Hes going to ride this presidential dream all the way to when reality sets in around 17 or so. Go Tristan!
Tristan told me that he intends to keep pursuing this doomed dream in the coming years, much like his friend Tanner Harrison, who has the laughably unachievable goal of becoming a heart surgeon.
Its an incredible feat of strength for such a young child. But ultimately, of course, as hard as things will be for young Tristan, one can only imagine itll be so much worse for the Tanners.
The post Heartwarming: This Second Grader Dreams of One Day Becoming President Despite Being Named Tristan appeared first on The Hard Times.
16:45
16:33
EEN OPEN BRIEF AAN ERNST KUIPERS "IndyWatch Feed Uncanny"
Heer Kuipers, Een weigering die de werking van de democratische rechtsstaat ondermijnt, dat is wat ik als Nederlander, en dus uw werkgever, kan opmaken uit dit artikel: https://twitter.com/volkskrant/status/1664564042252386304 U bent, Continue Reading
Het bericht EEN OPEN BRIEF AAN ERNST KUIPERS verscheen eerst op Take care 4.
16:24
Crop Circle ECLIPSE Announces the Arrival of a Huge Celestial Body (GIGANTIC MOTHERSHIP?) "IndyWatch Feed Spiritual"
16:17
What Did You Want to Do for a Long Time but Discovered You Didnt Like It? People Shared Their Stories. "IndyWatch Feed Arts"
It can be a bummer to really, REALLY want to do something for a long time and then find out that you dont like it.
At all.
But thats life, friends!
Here are some stories about this phenomenon from folks on AskReddit.
Not working out.
I want to be an environmental lawyer when I grow up! Im going to help save the world!
Fu**ing k**l me dude, I dont even have the energy to save myself anymore.
Never looked back.
All my life I wanted to make cartoons.
I fought with tooth and nail to reach the top.
Then I interned for an old studio in Burbank specializing in cartoons about a certain yellow family.
Then, after college, I became a mechanic and never looked back.
Need a new path.
Being an EMT.
I had planned on it being my lifelong career since middle school. I loved the medical field and wanted to save lives but knew I wouldnt have the stamina to get through medical school.
I got into training as soon as I graduated high school and I was top of my class in the educational sense, but as soon as I started doing ride-alongs everything just kind of fell apart on me.
I didnt fit in well with the firefighters, which sounds stupid but I think I really needed that brotherhood if I was going to survive in that field. The real problem, however, was my empathy.
I knew quickly that I would not be able to see people on their worst days everyday. I could deal with broken bones and blood, but I hadnt prepared myself for the screams.
On my third ride-along I responded to a teenage s**cide, and that was it for me. I work for a museum now.
Try it out first.
...
15:13
MUFG to facilitate Japanese bank-backed stablecoins via Progmat Coin platform "IndyWatch Feed Crypto"
Mitsubishi UFJ Financial Group hasnt revealed what firms will be the first to utilize its platform; however, a handful of banks have reportedly opted for a separate stablecoin solution.
14:12
Net Bitcoin ATMs record an increase after 4 months of global downtrend "IndyWatch Feed Crypto"
In the first four months of 2023, net crypto ATMs worldwide declined by 5,850.
13:59
Regional Drink Driver Says Its Just More Convenient To Run The Risk Of Tearing His Hometown Apart Than Get A Lift "IndyWatch Feed Satire"
WENDELL HUSSEY | Cadet | CONTACT A local man from Queenslands Wide Bay-Burnett region has today proven to friends, family and his community that he can be guilty of not thinking things through. After enjoying a few schooners of full strength followed by some of his hometowns finest, the Bundaberg man reportedly told his mates that he planned on []
The post Regional Drink Driver Says Its Just More Convenient To Run The Risk Of Tearing His Hometown Apart Than Get A Lift appeared first on The Betoota Advocate.
13:45
These Older Women Arent Ashamed To Admit What They Dont Get About The Younger Generation "IndyWatch Feed Arts"
There might be a lot of downsides to getting older (RIP your back and knees, for two things), but there are a ton of upsides, too like not really caring what people think anymore.
It can be confusing to look around and totally not get what the younger generation is up to in one way or another, and these older ladies would like some explanations.
Not enough crime dramas.
Letting everyone on the internet knowing exactly whare you are at all times and what your schedule is seems a bit nuts.
Theyre likely to regret it.
Buccal fat removal surgery.
Its permanent, and your body will never make more of it. Buccal fat removal ages the face immediately, which isnt a problem for most women in their 20s, but as they actually do age, there is a high likelihood that they will need to constantly get fillers for the rest of their life to combat the side effects of significant premature aging.
I cant even imagine.
My stepdaughter is often upset, since moving in at my house, because her friends get together and dont invite her (even though weve offered to drive). The same thing was probably true of me when I moved in to my stepdads house, but tiktok wasnt around to create all this evidence that everyone is having fun without you.
Social media is a disease, especially for young people, in a lot of very subtle ways. That s*%t is going to happen, and feelings are going to get hurt, because youre making it public record the who and when of your hangouts.
So goofy.
The overdone lip injections. I cant wait for this trend to die....
13:45
Hello! "IndyWatch Feed Survival"
Hello from this side of the world!
12:19
Microsoft pens AI cloud computing deal with former Ethereum miner CoreWeave: CNBC "IndyWatch Feed Crypto"
The reported deal comes just a few days after CoreWeave announced an additional $200 million worth of funding via an extended Series B funding round.
12:17
Reaffirming a positive correlation between number of vaccine doses and infant mortality rates. "IndyWatch Feed Health"
PMID: Cureus. 2023 Feb ;15(2):e34566. Epub 2023 Feb 2. PMID: 36751569 Abstract Title: Reaffirming a Positive Correlation Between Number of Vaccine Doses and Infant Mortality Rates: A Response to Critics. Abstract: Introduction In 2011, we published a study that found a counterintuitive, positive correlation,= 0.70 (
12:00
New Upcycle Ideas 680 "IndyWatch Feed Craft"
Visit 20+ New Upcycle Ideas 680 vintage sewing machine
bookends, bee cups, wooden ruler flag, vintage blueprint art, plus
more repurposed projects with tutorials! New Upcycle Ideas 680
Every Friday, 7 PM through Wednesday 11 PM Pacific
Greetings! Welcome to another riveting and fun weekend of inspiring
repurposed projects to make with things []
The post New Upcycle Ideas 680 appeared first on Funky Junk Interiors.
11:36
Moringa oleifera leaf attenuate osteoporosis in ovariectomized rats by modulating gut microbiota composition. "IndyWatch Feed Health"
PMID: Biomed Pharmacother. 2023 May ;161:114434. Epub 2023 Feb 23. PMID: 36841025 Abstract Title: Moringa oleifera leaf attenuate osteoporosis in ovariectomized rats by modulating gut microbiota composition and MAPK signaling pathway. Abstract: Moringa oleifera leaf (MLP) contains abundant complex nutrients with anti-osteoporosis potential. However, its efficacy and mechanisms against osteoporosis remain unknown. The purpose of this research is to investigate MLP's anti-osteoporotic effects and mechanisms. Animal experiments were used in this work to validate MLP's anti-osteoporotic efficacy. We investigated the mode of action of MLP, analyzed its impact on the gut microbiota, and predicted and validated its anti-osteoporosis-related molecular targets and pathways through network pharmacology, molecular docking, and western blotting. In an ovariectomized osteoporosis rat model, MLP significantly increased bone mineral density and improved bone metabolism-related indicators, bone microstructure, and lipid profile. Moreover, it improved gut microbiota composition and increased the expression of Occludin and Claudin-1 protein in the duodenum. Network pharmacology identified a total of 97 active ingredients and 478 core anti-osteoporosis targets. Of these, MAPK1 (also known as ERK2), MAPK3 (also known as ERK1), and MAPK8 (also known as JNK) were successfully docked with the active constituents of MLP. Interestingly, MLP increased ERK and VAV3 protein expression and decreased p-ERK and JNK protein expression in the femur. These findings confirm MLP's anti-osteoporotic efficacy, which could be mediated via regulation of gut microbiota and MAPK signaling.
11:33
M. oleifera leaf extract protein had a marked effect on the biofilm growth or formation by Staphylococcus aureus. "IndyWatch Feed Health"
PMID: Protein Pept Lett. 2023 ;30(2):116-125. PMID: 36734904 Abstract Title: Disruption ofBiofilms with PurifiedLeaf Extract Protein. Abstract: BACKGROUND: A major cause of economic losses in the medical implant sector has been bacterial biofilms due to their ability to persist on various surfaces and their tolerance against endogenous defences, antibiotics, or other anti-microbial agents. The quest for potential sources causing inhibition or disruption of bacterial biofilms has been taken up to alleviate the loss. Plantderived extracts such as essential oils, bioactive compounds and other solvent extracts are regularly being used instead of antibiotics and other synthetic compounds as they are safer, economical, and in many instances, have an elaborate history of traditional medicinal usage.OBJECTIVES: As a plant that has been traditionally used over the centuries, the Moringa oleifera Lam., or more commonly the drumstick tree, is being tapped for myriad pharmaceutical applications. The protein-rich leaf of this tree has not only proved to be of great nutritional value but also divulged numerous potential therapeutic applications.METHODS: While reports of proteinaceous components are rare, here we report the efficacy of the aqueous extract of the leaf of M. oleifera and a 62 kDa protein component in the disruption of staphylococcal biofilms, which are largely implicated in nosocomial infections.RESULTS: The application of the M. oleifera leaf extract protein had a marked effect on the biofilm growth or formation by Staphylococcus aureus.CONCLUSION: While the crude extract itself showed considerable disruption of biofilm formation, the application of the purified protein obtained after a two-step process led to a significant increase in the anti-biofilm activity.
11:31
Combined non-psychoactive cannabis components cannabidiol and -caryophyllene reduce chronic pain. "IndyWatch Feed Health"
PMID: PLoS One. 2023 ;18(3):e0282920. Epub 2023 Mar 13. PMID: 36913400 Abstract Title: Combined non-psychoactive Cannabis components cannabidiol and-caryophyllene reduce chronic pain via CB1 interaction in a rat spinal cord injury model. Abstract: The most frequently reported use of medical marijuana is for pain relief. However, its psychoactive component9-tetrahydrocannabinol (THC) causes significant side effects. Cannabidiol (CBD) and-caryophyllene (BCP), two other cannabis constituents, possess more benign side effect profiles and are also reported to reduce neuropathic and inflammatory pain. We evaluated the analgesic potential of CBD and BCP individually and in combination in a rat spinal cord injury (SCI) clip compression chronic pain model. Individually, both phytocannabinoids produced dose-dependent reduction in tactile and cold hypersensitivity in male and female rats with SCI. When co-administered at fixed ratios based on individual A50s, CBD and BCP produced enhanced dose-dependent reduction in allodynic responses with synergistic effects observed for cold hypersensitivity in both sexes and additive effects for tactile hypersensitivity in males. Antinociceptive effects of both individual and combined treatment were generally less robust in females than males. CBD:BCP co-administration also partially reduced morphine-seeking behavior in a conditioned place preference (CPP) test. Minimal cannabinoidergic side effects were observed with high doses of the combination. The antinociceptive effects of the CBD:BCP co-administration were not altered by either CB2 or-opioid receptor antagonist pretreatment but, were nearly completely blocked by CB1 antagonist AM251. Since neither CBD or BCP are thought to mediate antinociception via CB1 activity, these findings suggest a novel CB1 interactive mechanism between these two phytocannabinoids in the SCI pain state. Together, these findings suggest that CBD:BCP co-administration may provide a safe and effective treatment option for the management of chronic SCI pain.
11:29
Phytochemical composition and antimicrobial activity of essential oil from the leaves of Artemisia vulgaris. "IndyWatch Feed Health"
PMID: Molecules. 2023 Feb 28 ;28(5). Epub 2023 Feb 28. PMID: 36903525 Abstract Title: Phytochemical Composition and Antimicrobial Activity of Essential Oil from the Leaves ofL. Abstract: is an enormously useful aromatic plant known for its insecticidal, antifungal, parasiticidal, and medicinal values. The main aim of this study is to investigate phytochemical contents and the potential antimicrobial activities ofessential oil (AVEO) from the fresh leaves ofgrown in Manipur. The AVEO isolated by hydro-distillation fromwere analyzed by gas chromatography/mass spectrometry and solid-phase microextraction-GC/MS to describe their volatile chemical profile. There were 47 components identified in the AVEO by GC/MS, amounting to 97.66% of the total composition, while 97.35% were identified by SPME-GC/MS. The prominent compounds present in AVEO analyzed by direct injection and SPME methods are found to be eucalyptol (29.91% and 43.70%), sabinene (8.44% and 8.86%), endo-Borneol (8.24% and 4.76%), 2,7-Dimethyl-2,6-octadien-4-ol (6.76% and 4.24%), and 10-epi--Eudesmol (6.50% and 3.09%). The consolidated component in the leaf volatiles comes to the terms of monoterpenes. The AVEO exhibits antimicrobial activities against fungal pathogens such as(ITCC 4107) and(MTCC 9913) and bacterial cultures such as(ATCC 13061) and(ATCC 25923). The percent inhibition of AVEO against theandwas found up to 50.3% and 33.13%, respectively. The MIC and MBC of the essential oil tested forandwere found to be (0.3%, 0.63%) and (0.63%, 2.5%), respectively. Finally, the results revealed that the AVEO characterized by the hydro-distillation and SPME extraction yielded the same chemical profile and showed potent antimicrobial activities. Further research intoantibacterial properties can be performed in order to use it as a source for natural antimicrobial medications.
11:27
Antiviral activities of Artemisia vulgaris L. extract against herpes simplex virus. "IndyWatch Feed Health"
PMID: Chin Med. 2023 Feb 28 ;18(1):21. Epub 2023 Feb 28. PMID: 36855145 Abstract Title: Antiviral activities of Artemisia vulgaris L. extract against herpes simplex virus. Abstract: BACKGROUND: Artemisia vulgaris L. is often used as a traditional Chinese medicine with the same origin of medicine and food. Its active ingredient in leaves have multiple biological functions such as anti-inflammatory, antibacterial and insecticidal, anti-tumor, antioxidant and immune regulation, etc. It is confirmed that folium Artemisiae argyi has obvious anti-HBV activity, however, its antiviral activity and mechanism against herpesvirus or other viruses are not clear. Hence, we aimed to screen the crude extracts (Fr.8.3) isolated and extracted from folium A. argyi to explore the anti-herpesvirus activity and mechanism.METHODS: The antiherpes virus activity of Fr.8.3 was mainly characterized by cytopathic effects, real-time PCR detection of viral gene replication and expression levels, western blotting, viral titer determination and plaque reduction experiments. The main components of Fr.8.3 were identified by using LC-MS, and selected protein targets of these components were investigated through molecular docking.RESULTS: We collected and isolated a variety of A. vulgaris L. samples from Tangyin County, Henan Province and then screened the A. vulgaris L. leaf extracts for anti-HSV-1 activity. The results of the plaque reduction test showed that the crude extract of A. vulgaris L.-Fr.8.3 had anti-HSV-1 activity, and we further verified the anti-HSV-1 activity of Fr.8.3 at the DNA, RNA and protein levels. Moreover, we found that Fr.8.3 also had a broad spectrum of antiviral activity. Finally, we explored its anti-HSV-1 mechanism, and the results showed that Fr.8.3 exerted an anti-HSV-1 effect by acting directly on the virus itself. Then, the extracts were screened on HSV-1 surface glycoproteins and host cell surface receptors for potential binding ability by molecular docking, which further verified the phenotypic results. LC-MS analysis showed that 1 and 2 were the two main components of the extracts. Docking analysis suggested that compounds from extract 1 might similarly cover the binding domain between the virus and the host cells, thus interfering with virus adhesion to cell receptors, which provides new ideas and insights for clinical drug development for herpes simplex virus type 1.CONCLUSION: We found that Fr.8.3 has anti-herpesvirus and anti-rotavirus effects. The main 12 components in Fr.8.3 were analyzed by LC-MS, and the protein targets were finally predicted through molecular docking, which showed that alkaloids may play a major role in antiviral activity.
...
11:25
Artemisia afra and Artemisia annua extracts have bactericidal activity against Mycobacterium tuberculosis. "IndyWatch Feed Health"
PMID: Pathogens. 2023 Feb 1 ;12(2). Epub 2023 Feb 1. PMID: 36839499 Abstract Title: andExtracts Have Bactericidal Activity againstin Physiologically Relevant Carbon Sources and Hypoxia. Abstract: (Mtb) is a deadly pathogen and causative agent of human tuberculosis, causing ~1.5 million deaths every year. The increasing drug resistance of this pathogen necessitates novel and improved treatment strategies. A crucial aspect of the host-pathogen interaction is bacterial nutrition. In this study,anddichloromethane extracts were tested for bactericidal activity against Mtb strain mc6230 under hypoxia and various infection-associated carbon sources (glycerol, glucose, and cholesterol). Both extracts showed significant bactericidal activity against Mtb, regardless of carbon source. Based on killing curves,showed the most consistent bactericidal activity against Mtb for all tested carbon sources, whereasshowed the highest bactericidal activity in 7H9 minimal media with glycerol. Both extracts retained their bactericidal activity against Mtb under hypoxic conditions. Further investigations are required to determine the mechanism of action of these extracts and identify their active constituent compounds.
11:22
Ferulic acid alleviates high fat diet-induced cognitive impairment by inhibiting oxidative stress and apoptosis. "IndyWatch Feed Health"
PMID: Eur J Pharmacol. 2023 May 5 ;946:175642. Epub 2023 Mar 3. PMID: 36871664 Abstract Title: Ferulic acid alleviates high fat diet-induced cognitive impairment by inhibiting oxidative stress and apoptosis. Abstract: Cognitive impairment has become a major public health problem. Growing evidence suggests that high-fat diet (HFD) can cause cognitive dysfunction and increase the risk of dementia. However, effective treatment for cognitive impairment is not available. Ferulic acid (FA) is a single phenolic compound with anti-inflammatory and antioxidant properties. Nevertheless, its role in regulating learning and memory in HFD-fed mice and the underlying mechanism remains unclear. In this study, we aimed to identify the neuroprotective mechanisms of FA in HFD induced cognitive impairment. We found that FA improved the survival rate of HT22 cells treated with palmitic acid (PA), inhibited cell apoptosis, and reduced oxidative stress via the IRS1/PI3K/AKT/GSK3signaling pathway; Furthermore, FA treatment for 24 weeks improved the learning and memory of HFD-fed mice and decreased hyperlipidemia. Moreover, the expression of Nrf2 and Gpx4 proteins were decreased in HFD-fed mice. After FA treatment, the decline of these proteins was reversed. Our study showed that the neuroprotective effect of FA on cognitive impairment was related to the inhibition of oxidative stress and apoptosis and regulation of glucose and lipid metabolism. These findings suggested that FA can be developed as a potential agent for the treatment of HFD-induced cognitive impairment.
11:20
Renoprotective effects of tanshinone IIA: A literature review. "IndyWatch Feed Health"
PMID: Molecules. 2023 Feb 20 ;28(4). Epub 2023 Feb 20. PMID: 36838978 Abstract Title: Renoprotective Effects of Tanshinone IIA: A Literature Review. Abstract: The kidney is an important organ in the human body, with functions such as urine production, the excretion of metabolic waste, the regulation of water, electrolyte and acid-base balance and endocrine release. The morbidity and mortality of kidney diseases are increasing year by year worldwide, and they have become a serious public health problem. In recent years, natural products derived from fungi, plants and animals have become an important alternative source of treatment for kidney diseases because of their multiple pathways, multiple targets, safety, low toxicity and few side effects. Tanshinone IIA (Tan IIA) is a lipid-soluble diterpene quinone isolated from the Chinese herb, considered as a common drug for the treatment of cardiovascular diseases. As researchers around the world continue to explore its unknown biological activities, it has also been found to have a wide range of biological effects, such as anti-cancer, anti-oxidative stress, anti-inflammatory, anti-fibrotic, and hepatoprotective effects, among others. In recent years, many studies have elaborated on its renoprotective effects in various renal diseases, including diabetic nephropathy (DN), renal fibrosis (RF), uric acid nephropathy (UAN), renal cell carcinoma (RCC) and drug-induced kidney injury caused by cisplatin, vancomycin and acetaminophen (APAP). These effects imply that Tan IIA may be a promising drug to use against renal diseases. This article provides a comprehensive review of the pharmacological mechanisms of Tan IIA in the treatment of various renal diseases, and it provides some references for further research and clinical application of Tan IIA in renal diseases.
11:20
Getting On "IndyWatch Feed Literature"
who would I be
clean white socks
positive outlook
after everything
still getting on
10:45
This College Student Thinks They Know Why Its So Hard For Young People To Find A Job "IndyWatch Feed Arts"
Image Credit: TikTok
The world has changed in many ways that are easy to consider positive.
There are also lots of things that have made life harder for those entering adulthood over the past 20 years like, for example, finding a job after college.
According to Trading Economics, there were 9.6 million unfilled jobs in the US in March of 2023. That said, people still have trouble finding a job that offers a salary high enough to afford basic living expenses.
10:41
Astragaloside IV attenuates myocardial dysfunction in diabetic cardiomyopathy. "IndyWatch Feed Health"
PMID: Phytother Res. 2023 Mar 7. Epub 2023 Mar 7. PMID: 36882189 Abstract Title: Astragaloside IV attenuates myocardial dysfunction in diabetic cardiomyopathy rats through downregulation of CD36-mediated ferroptosis. Abstract: Diabetic cardiomyopathy (DCM), one of the major complications of type 2 diabetes, is a leading cause of heart failure and death in advanced diabetes. Although there is an association between DCM and ferroptosis in cardiomyocytes, the internal mechanism of ferroptosis leading to DCM development remains unknown. CD36 is a key molecule in lipid metabolism that mediates ferroptosis. Astragaloside IV (AS-IV) confers various pharmacological effects such as antioxidant, anti-inflammatory, and immunomodulatory. In this study, we demonstrated that AS-IV was able to recover the dysfunction of DCM. In vivo experiments showed that AS-IV ameliorated myocardial injury and improved contractile function, attenuated lipid deposition, and decreased the expression level of CD36 and ferroptosis-related factors in DCM rats. In vitro experiments showed that AS-IV decreased CD36 expression and inhibited lipid accumulation and ferroptosis in PA-induced cardiomyocytes. The results demonstrated that AS-IV decreased cardiomyocyte injury and myocardial dysfunction by inhibiting ferroptosis mediated by CD36 in DCM rats. Therefore, AS-IV regulated the lipid metabolism of cardiomyocytes and inhibited cellular ferroptosis, which may have potential clinical value in DCM treatment.
10:29
Astragaloside IV, as a potential anticancer agent. "IndyWatch Feed Health"
PMID: Front Pharmacol. 2023 ;14:1065505. Epub 2023 Feb 17. PMID: 36874003 Abstract Title: Astragaloside IV, as a potential anticancer agent. Abstract: Cancer is a global intractable disease, and its morbidity and mortality are increasing year by year in developing countries. Surgery and chemotherapy are often used to treat cancer, but they result in unsatisfactory outcomes, such as severe side effects and drug resistance. With the accelerated modernization of traditional Chinese medicine (TCM), an increasing body of evidence has shown that several TCM components have significant anticancer activities. Astragaloside IV (AS-IV) is considered the main active ingredient of the dried root of. AS-IV exhibits various pharmacological effects, such as anti-inflammatory, hypoglycemic, antifibrotic, and anticancer activities. AS-IV possesses a wide range of activities, such as the modulation of reactive oxygen species-scavenging enzyme activities, participation in cell cycle arrest, induction of apoptosis and autophagy, and suppression of cancer cell proliferation, invasiveness, and metastasis. These effects are involved in the inhibition of different malignant tumors, such as lung, liver, breast, and gastric cancers. This article reviews the bioavailability, anticancer activity, and mechanism of AS-IV and provides suggestions for further research of this TCM.
10:25
Astragaloside IV attenuates neuroinflammation and ameliorates cognitive impairment in Alzheimer's disease. "IndyWatch Feed Health"
PMID: Heliyon. 2023 Feb ;9(2):e13411. Epub 2023 Feb 3. PMID: 36820018 Abstract Title: Astragaloside IV attenuates neuroinflammation and ameliorates cognitive impairment in Alzheimer's disease via inhibiting NF-B signaling pathway. Abstract: The inflammatory process plays a significant role in the pathophysiology of Alzheimer's disease (AD). Anti-neuroinflammatory cascade is now considered an important measure for AD treatment. Astragaloside IV (AS-IV), a saponin of Astragali radix, has shown significant anti-inflammatory properties and protective effects against neurodegenerative diseases. However, the mechanisms of AS-IV in treating Alzheimer's disease (AD) have not been fully determined. The experiment research was carried out to comprehensively confirm the beneficial effects and underlying molecular mechanisms of AS-IV to AD. In this research, BV-2 cells were culturedand treated by AS-IV under the stimulation of LPS, qRT-PCR was adopted to analyze the mRNA expression level of inflammatory factors. Western-blot was carried out to analyze the phosphorylation level of NF-B signaling pathway. 5xFAD mice were administrated AS-IV mixed in the diet for 3 months. Behavioral experiments were adopted to analyze learning and memory abilities. Immunohistochemical staining was adopted to observe the proliferation of microglias and the accumulation of Aplaques. AS-IV cut down the mRNA expression of IL-1, COX-2, iNOS and TNF-in LPS-stimulated BV-2 cells by suppressing the phosphorylation of IB and p65, and inhibited the phosphorylated p65 from entering the nucleus. AS-IV increased the frequency of recognizing new objects in the novel object recognition test, shortened the escape latency, raised the number of crossing platform in the Morris water maze, inhibited the hyperplasia of microglias, and reduced the production of senile plaques in 5xFAD mice. In brief, AS-IV ameliorates learning and memory impairment by relieving the intensity of neuroinflammatory response in AD. Therefore, AS-IV is very promising to be a herbal medicine for AD treatment.
10:20
Tanshinone IIA relieves arthritis by inhibiting autophagy of fibroblast-like synoviocytes. "IndyWatch Feed Health"
n/a PMID: Phytother Res. 2023 Apr ;37(4):1391-1404. Epub 2023 Feb 28. PMID: 36852883 Abstract Title: Tanshinone IIA relieves arthritis by inhibiting autophagy of fibroblast-like synoviocytes via matrix metalloproteinase9/receptor for advanced glycation end product/toll-like receptor 9 signal axis in mice with collagen-induced arthritis. Abstract: In this study, we probed into the related mechanism underlying the role of Tanshinone IIA (TIIA) in RA fibroblast-like synoviocytes (RA-FLSs). We constructed a mouse model of RA using the collagen-induced arthritis (CIA) method. Gain- or loss-of-function approaches were used to manipulate matrix metalloproteinase9 (MMP9), receptor for advanced glycation end product (RAGE), and toll-like receptor 9 (TLR9) in both CIA mice and RA-FLSs following treatment with TIIA to study the in vivo and in vitro effect of TIIA through analysis of cell viability, and measurement of autophagy and inflammatory proteins as well as severity of RA. In vitro and in vivo animal experiments results showed that TIIA could inhibit the proliferation of RA-FLSs and affect autophagy, thereby improving the symptoms of RA in mice. Mechanically, TIIA could inhibit the expression of MMP9 in RA-FLSs, thereby inhibiting the shedding of RAGE and thus inhibiting the activation of TLR9. Finally, animal experiments confirmed that TIIA affected autophagy by regulating the MMP9/RAGE/TLR9 axis, and finally improve the symptoms of RA in mice. Conclusively, TIIA may inhibit expression of MMP9 to suppress the combination of RAGE and TLR9, thereby inhibiting RA-FLS proliferation and affecting autophagy, eventually improve the RA.
10:17
Tanshinone IIA and hepatocellular carcinoma. "IndyWatch Feed Health"
PMID: Front Oncol. 2023 ;13:1071415. Epub 2023 Jan 31. PMID: 36798821 Abstract Title: Tanshinone IIA and hepatocellular carcinoma: A potential therapeutic drug. Abstract: Because of its high prevalence and poor long-term clinical treatment effect, liver disease is regarded as a major public health problem around the world. Among them, viral hepatitis, fatty liver, cirrhosis, non-alcoholic fatty liver disease (NAFLD), and autoimmune liver disease are common causes and inducements of liver injury, and play an important role in the occurrence and development of hepatocellular carcinoma (HCC). Tanshinone IIA (TsIIA) is a fat soluble polyphenol of Salvia miltiorrhiza that is extracted from Salvia miltiorrhiza. Because of its strong biological activity (anti-inflammatory, antioxidant), it is widely used in Asia to treat cardiovascular and liver diseases. In addition, TsIIA has shown significant anti-HCC activity in previous studies. It not only has significant anti proliferation and pro apoptotic properties. It can also play an anti-cancer role by mediating a variety of signal pathways, including phosphatidylinositol-3-kinase (PI3K)/protein kinase B (Akt)/rapamycin (mTOR), mitogen-activated protein kinase (MAPK), and nuclear factor kappa-B (NF-B). This review not only reviews the existing evidence and molecular mechanism of TsIIA's anti-HCC effect but also reviews the liver-protective effect of TsIIA and its impact on liver fibrosis, NAFLD, and other risk factors for liver cancer. In addition, we also conducted network pharmacological analysis on TsIIA and HCC to further screen and explore the possible targets of TsIIA against hepatocellular carcinoma. It is expected to provide a theoretical basis for the development of anti-HCC-related drugs based on TsIIA.
10:12
Tanshinone IIA inhibits triple-negative breast cancer cells MDA-MB-231. "IndyWatch Feed Health"
PMID: Dis Markers. 2023 ;2023:8371623. Epub 2023 Jan 27. PMID: 36741908 Abstract Title: Tanshinone IIA Inhibits Triple-Negative Breast Cancer Cells MDA-MB-231 via G Protein-Coupled Estrogen Receptor- (GPER-) Dependent Signaling Pathway. Abstract: Due to the lack of classic estrogen receptors, there has been a shortage of targeted therapy for triple-negative breast cancer (TNBC), resulting in a poor prognosis. However, the newly discovered G protein-coupled estrogen receptor (GPER) has been found to be expressed in TNBC cells.(Danshen) is an essential Chinese medicine for gynecological disorders, and its component tanshinone IIA (Tan IIA) exerts an anticancer effect. Therefore, this study attempted to investigate whether GPER is involved in the inhibitory effect of Tan IIA on TNBC. We applied various databases and GO pathway analysis to predict the possible mechanism of Tan IIA. We identified 39 overlapping targets, including c-Jun, c-Fos, and caspase-3, and enriched cell cycle-related pathways. Next, we demonstrated the strong binding ability of Tan IIA to GPER by molecular docking assay. In the subsequent validation tests, Cell Counting Kit-8 (CCK8) assay showed that Tan IIA inhibited proliferation of MDA-MB-231 cells time and dose dependently without affecting normal cells. Using Transwell plate, flow cytometry, and Western blot assays, we showed that Tan IIA inhibited migration and induced apoptosis of MDA-MB-231 dose dependently. Importantly, protein expressions of GPER, epidermal growth factor receptor (EGFR), extracellular regulated protein kinases (ERK), c-Fos, and c-Jun were all decreased by Tan IIA dose dependently. Administration of GPER inhibitor partly abolished these effects. Furthermore, nuclear translocation of c-Fos and c-Jun as well as cell cycle-related proteins was downregulated by Tan IIA dose dependently. In summary, Tan IIA could inhibit the proliferation and migration of MDA-MB-231 cells and induce apoptosis, and the possible mechanism may be the regulation of GPER-mediated pathways, suggesting that GPER could be a therapeutic target for TNBC.
10:00
British Museum Drops Longtime Sponsor BP "IndyWatch Feed Arts"
Bowing to years of pressure and protests from climate change activists as well as academics and its own staffers, the British Museum has severed ties with BP. The oil and gas conglomerate had been a
Dore Destroys Krystal Balls Interview With RFK Jr. "IndyWatch Feed Health"
April 19, 2023, Robert F. Kennedy Jr. formally announced his 2024 Democratic presidential campaign.1 Early polls show hes got nearly 20% of the Democratic vote. Unfortunately, Democrat Party officials are doing everything they can to avoid public debates, and their media allies seem hellbent on not giving Kennedy the opportunity to share his views either.
May 17, 2023, Krystal Ball, cohost of the online show Breaking Point, interviewed Kennedy,2,3 or perhaps more accurately, debated him herself. Ball told Kennedy she disagrees with his views on vaccines, and claimed Democratic voters by and large share her opposition. According to Ball, Kennedys vaccine skepticism and antivaccine advocacy is a red line that disqualifies him from holding the highest office.
Antiscientific Shilling for Big Pharma
In the video playlist above, comedian Jimmy Dore of The Jimmy Dore Show dissects Balls hatchet job of an interview, pointing out Balls poor journalism, rudeness and irresponsible, antiscientific shilling for corporate interests.
She repeatedly interrupted Kennedy with Big Pharma talking points putting her own ignorance on public display and didnt allow him to answer her questions. Kennedy asked her to show him where he got things wrong many times, and she deflected with broad generalities.
When Kennedy pointed out that countries with the lowest COVID jab rates had far lower COVID cases and mortality, Ball insisted that there were many other factors that played into that, such as the high rate of obesity in America, and the fact that we dont spend as much time outside in the sun as people in Africa.
Never mind the fact that obesity and sun exposure recommendations were never part of the COVID response. Not only did U.S. health authorities not offer any guidance on reducing obesity, but they closed parks and beaches and told everyone to spend as little time outdoors as possible.
The only solution they provided was the vaccine. If it worked, we ought to have far better outcomes than countries like Africa that didnt follow our COVID response guidelines, like staying indoors and getting jabbed multiple times. But we didnt.
Basically, Ball is admitting seemingly without realizing it that factors such as obesity and sun exposure were more important than the jab, because places with lower obesity rates and greater sun exposure fared better e...
It's Been Three Years. Can You Hear Me Now? "IndyWatch Feed Health"
This story is about how to get through to the ones who are still under the "COVID spell." I would also like to poke the most inconvenient elephant in the room, and I would like to do so with love.
"How Do We Get Through to Them?"
In the past three years we have been on a very dramatic roller coaster ride. It is fair to say that we've been through hell. And the most traumatizing and maddening part has been seeing our loved ones succumb to the spell of the "COVID response" and behave like their souls have been stolen off.
For that reason, in our circles, it is very common to ask, "How do we get through to the ones who have acted out of character and who are still under the COVID spell?" First, I am going to answer this question in earnest and then, I am going to go to into the ideological "permafrost" and poke the giant elephant (or a wooly mammoth, rather) hiding there.
Patience Is a Virtue, Alas
There are no magical formulas. We in America are somewhat used to magical formulas, psychological "systems," and impressive consultants riding in on a white horse with a solution and an invoice.
But perhaps, the past three years showed up to strip us of that delusion and to demonstrate to us in the most visceral way that here we are, human beings between the earth and the sky, with a deep longing in our hearts and a clumsy prayer on our lips. And perhaps, that longing in our heart and that imperfect prayer on our lips are all we have and it's a start.
Getting through to ideological addicts is a time-consuming and difficult feat, and we get through by being patient, by not despairing, and by respecting their free will which I think can only be done if there is a total and massive self-love in us, a massive love for them, and a total spiritual confidence in good things.
It is also important to make honest assessments in real time as to when to talk to them and when to let them be, perhaps for a while. Also, prayer helps, and it doesn't have to be an institutional prayer. Prayer is prayer. The Creator is intelligent enough to understand our hearts.
Personally, I believe with passion that the lesson of the past three years is not about how to be better at marketing and arm-twisting than the ones on the dark side. In fact, I think it's not possible to compete in the dark art of bending free will and arm twisting with the ones on the dark side without joining their team.
That's the end of that story, really. If one does not have one's eyes and one's heart on honest healing and free will, and if one is not prepared to do the work but also relax and trust the universe (God, higher powers, however we think about those things) to make things right, one is just merely torturing himself or herself over what he or she cannot very quickly change.
And, if we are on t...
09:59
Tanshinone IIA alleviates lipopolysaccharide-induced renal tubular epithelial cell apoptosis. "IndyWatch Feed Health"
PMID: Nan Fang Yi Ke Da Xue Xue Bao. 2022 Dec 20 ;42(12):1852-1857. PMID: 36651254 Abstract Title: [Tanshinone IIA alleviates lipopolysaccharide-induced renal tubular epithelial cell apoptosis by inhibiting RIP3/FUNDC1 signaling pathway]. Abstract: OBJECTIVE: To investigate the effect of tanshinone IIA pretreatment on acute renal injury in lipopolysaccharide (LPS)-induced septic mice and explore the possible mechanism.METHODS: Thirty C57BL/6 mice were randomized for treatment with saline (control), 10 mg/kg LPS for 24 h, or 10 mg/kg tanshinone IIA 15 min before LPS treatment. After the treatments, serum creatinine and blood urea nitrogen levels of the mice were detected, renal pathologies were observed with PAS staining, and renal expressions of RIP3, cleaved caspase-3 and p-FUNDC1 were detected with Western blotting. In the cell experiment, cultured normal human renal tubular epithelial cells (HK-2) were treated with LPS (10 mg/mL), LPS+ siNC, LPS+ siRIP3, or LPS+tanshinone IIA (10 mg/L), and the changes in cell apoptosis were examined with TUNEL staining; Western blotting was performed to detect the expression levels of RIP3, cleaved caspase-3 and p-FUNDC1, and qRT-PCR was used to detect the expression of RIP3 mRNA.RESULTS: LPS challenge for 24 h significantly increased serum creatinine and blood urea nitrogen levels in the mice, caused obviously damages in the proximal renal tubules, and increased renal expressions of RIP3, cleaved caspase-3 and p-FUNDC1 proteins. Tanshinone IIA pretreatment significantly improved LPS-induced renal injury in the mice, alleviated apoptosis of the renal cells, and inhibited the expressions of RIP3, cleaved caspase-3 and p-FUNDC1 proteins. In HK-2 cells, LPS stimulation significantly increased the protein expressions of RIP3, cleaved caspase-3 and p-FUNDC1 and induced obvious cell apoptosis. Pretreatment with tanshinone IIA strongly inhibited the expression of RIP3 and p-FUNDC1 and reduced LPS-induced apoptosis of HK-2 cells.CONCLUSION: Tanshinone IIA can reduce LPS-induced apoptosis of renal tubular epithelial cells by inhibiting RIP3/FUNDC1 signal pathway.
09:53
The Art of Human Connection: Pioneering Psychologist and Philosopher William James on the Most Important Attitude for Relationships "IndyWatch Feed Arts"
Neither the whole of truth nor the whole of good is revealed to any single observer.
To be human is to continually mistake our frames of reference for reality itself. We so readily forget that our vantage point is but a speck on the immense plane of possible perspectives. We so readily forget that there are infinitely many kinds of beautiful lives.
The discipline of countering our reflex for self-righteousness is a triumph of existential maturity one increasingly rare in a culture where most people would rather armor themselves with judgment than tremble with uncertainty, would rather be right than understand.
The pioneering psychologist and philosopher William James (January 11, 1842August 26, 1910), who coined the term stream of consciousness, explores the making of that triumph in a pair of wonderful lectures On a Certain Blindness in Human Beings and What Makes Life Significant posthumously collected in the 1911 volume Talks to Teachers on Psychology: And to Students on Some of Lifes Ideals (public library | public domain).
09:46
Tanshinone IIa attenuates vascular calcification. "IndyWatch Feed Health"
PMID: Sheng Li Xue Bao. 2022 Dec 25 ;74(6):949-958. PMID: 36594383 Abstract Title: [Tanshinone IIa attenuates vascular calcification through inhibition of NF-B and-catenin signaling pathways]. Abstract: Tanshinone IIa is a key ingredient extracted from the traditional Chinese medicine Salvia miltiorrhiza (Danshen), and is widely used to treat various cardiovascular diseases. Vascular calcification is a common pathological change of cardiovascular tissues in patients with chronic kidney disease, diabetes, hypertension and atherosclerosis. However, whether Tanshinone IIa inhibits vascular calcification and the underlying mechanisms remain largely unknown. This study aims to investigate whether Tanshinone IIa can inhibit vascular calcification using high phosphate-induced vascular smooth muscle cell and aortic ring calcification model, and high dose vitamin D(vD)-induced mouse models of vascular calcification. Alizarin red staining and calcium quantitative assay showed that Tanshinone IIa significantly inhibited high phosphate-induced vascular smooth muscle cell and aortic ring calcification. qPCR and Western blot showed that Tanshinone IIa attenuated the osteogenic transition of vascular smooth muscle cells. In addition, Tanshinone IIa also significantly inhibited high dose vD-induced mouse aortic calcification and aortic osteogenic transition. Mechanistically, Tanshinone IIa inhibited the activation of NF-B and-catenin signaling in normal vascular smooth muscle cells. Similar to Tanshinone IIa, inhibition of NF-B and-catenin signaling using the chemical inhibitors SC75741 and LF3 attenuated high phosphate-induced vascular smooth muscle cell calcification. These results suggest that Tanshinone IIa attenuates vascular calcification at least in part through inhibition of NF-B and-catenin signaling, and Tanshinone IIa may be a potential drug for the treatment of vascular calcification.
09:43
Tanshinone IIA represses the progression of non-small cell lung cancer. "IndyWatch Feed Health"
PMID: Mol Cell Biochem. 2022 Dec 31. Epub 2022 Dec 31. PMID: 36586093 Abstract Title: Tanshinone IIA (TSIIA) represses the progression of non-small cell lung cancer by the circ_0020123/miR-1299/HMGB3 pathway. Abstract: Tanshinone IIA (TSIIA), a multi-pharmaceutical compound, has been demonstrated to have anti-tumor properties. This study explores the potential regulatory mechanism of TSIIA on non-small cell lung cancer (NSCLC) progression. The cytotoxicity of TSIIA was evaluated by MTT (3-(4,5-Dimethylthiazol-2-yl)-2,5-Diphenyltetrazolium Bromide) and LDH (lactate dehydrogenase) assays. Expression levels of circ_0020123 (hsa_circ_0020123) and microRNA-1299 (miR-1299) were assessed by quantitative real-time polymerase chain reaction (qRT-PCR). Cell proliferation, migration, invasion, and apoptosis were analyzed by MTT, colony formation, transwell, wound-healing, or flow cytometry assays. The relationship between miR-1299 and circ_0020123 or HMGB3 (high mobility group box 3) was verified by the dual-luciferase reporter and/or RNA immunoprecipitation (RIP) assays. Protein level of HMGB3 was measured by western blotting. The relationship between TSIIA and circ_0020123 was confirmed by xenograft assay. TSIIA reduced xenograft tumor growth in vivo and repressed proliferation, migration, invasion, and facilitated apoptosis of NSCLC cells in vitro. TSIIA reduced circ_0020123 and HMGB3 expression, whereas elevated miR-1299 expression in NSCLC cells. Circ_0020123 knockdown enhanced the repressive influence of TSIIA treatment on the malignancy of NSCLC cells in vitro and in vivo. Circ_0020123 sponged miR-1299 to regulate HMGB3 expression under TSIIA treatment. MiR-1299 inhibitor reversed circ_0020123 knockdown-mediated influence on malignant behaviors of NSCLC cells under TSIIA treatment. HMGB3 elevation offset the suppressive impact of miR-1299 mimic on the malignancy of NSCLC cells under TSIIA treatment. TSIIA curbed NSCLC progression by the circ_0020123/miR-1299/HMGB3 axis, manifesting that the TSIIA/circ_0020123/miR-1299/HMG regulatory network might be a potential treatment strategy for NSCLC.
09:42
Tanshinone IIA improves acute gouty arthritis. "IndyWatch Feed Health"
PMID: Dis Markers. 2022 ;2022:5851412. Epub 2022 Dec 19. PMID: 36578443 Abstract Title: Tanshinone IIA Improves Acute Gouty Arthritis in Rats through Regulating Neutrophil Activation and the NLRP3 Inflammasome. Abstract: OBJECTIVES: To investigate the prevention and treatment effect of tanshinone IIA (TIIA) on acute gouty arthritis (AGA) and its mechanism.METHODS: The anti-AGA effect of TIIA was observedand. Neutrophils were isolated from the abdominal cavity of mice, and the anti-AGA effect of TIIA was investigated in a rat model of MSU-induced AGA. The pathological changes of the ankle joint tissues were assessed by H&E. Cytokine and chemokine expression were determined by ELISA and RT-qPCR. The NLRP3 inflammasome pathway protein levels in the ankle joint tissues were evaluated via western blotting. Neutrophil migration was evaluated in air pouch and transwell assays. Immunohistochemistry and immunofluorescence analysis evaluate the release of myeloperoxidase (MPO), neutrophil elastase (NE), and citrullination of histone H3 (CitH3). Beclin-1 and LC3B expressions were determined using western blotting and immunofluorescence.. Treatment with TIIA alleviated synovial hyperplasia and neutrophil infiltration, regulated cytokine and chemokine expressions, and inhibited NLRP3 activation in AGA rats, neutrophil migration, MPO, NE, and CitH3 expression, and LC3B and Beclin-1 protein expression.CONCLUSIONS: These results demonstrate that TIIA can effectively enhance AGA by focusing on the neutrophils and NLRP3 inflammasome, demonstrating that TIIA may act as a potential helpful agent for AGA.
09:40
Crypto Lender Celsius $800M Ether Staking Shake-Up Stretches Ethereum Validator Queue to 44 Days "IndyWatch Feed Crypto"
Celsius deposits ETH into staking contracts (Arkham Intelligence)
09:38
Salvianolic acid B attenuates hypertrophic scar formation. "IndyWatch Feed Health"
PMID: Aesthetic Plast Surg. 2023 Feb 21. Epub 2023 Feb 21. PMID: 36810832 Abstract Title: Salvianolic Acid B Attenuates Hypertrophic Scar Formation In Vivo and In Vitro. Abstract: BACKGROUND: Hypertrophic scars (HTSs) are a fibroproliferative disorder that occur following skin injuries. Salvianolic acid B (Sal-B) is an extractant from Salvia miltiorrhiza that has been reported to ameliorate fibrosis in multiple organs. However, the antifibrotic effect on HTSs remains unclear. This study aimed to determine the antifibrotic effect of Sal-B in vitro and in vivo.METHODS: In vitro, hypertrophic scar-derived fibroblasts (HSFs) were isolated from human HTSs and cultured. HSFs were treated with (0, 10, 50, 100mol/L) Sal-B. Cell proliferation and migration were evaluated by EdU, wound healing, and transwell assays. The protein and mRNA levels of TGFI, Smad2, Smad3,-SMA, COL1, and COL3 were detected by Western blots and real-time PCR. In vivo, tension stretching devices were fixed on incisions for HTS formation. The induced scars were treated with 100L of Sal-B/PBS per day according to the concentration of the group and followed up for 7 or 14 days. The scar condition, collagen deposition, and-SMA expression were analyzed by gross visual examination, H&E, Masson, picrosirius red staining, and immunofluorescence.RESULTS: In vitro, Sal-B inhibited HSF proliferation, migration, and downregulated the expression of TGFI, Smad2, Smad3,-SMA, COL1, and COL3 in HSFs. In vivo, 50 and 100mol/L Sal-B significantly reduced scar size in gross and cross-sectional observations, with decreased-SMA expression and collagen deposition in the tension-induced HTS model.CONCLUSIONS: Our study demonstrated that Sal-B inhibits HSFs proliferation, migration, fibrotic marker expression and attenuates HTS formation in a tension-induced HTS model in vivo.NO LEVEL ASSIGNED: This journal requires that authors assign a level of evidence to each submission to which Evidence-Based Medicine rankings are applicable. This excludes Review Articles, Book Reviews, and manuscripts that concern Basic Science, Animal Studies, Cadaver Studies, and Experimental Studies. For a full description of these Evidence-Based Medicine ratings, please refer to the Table of Contents or the online Instructions to Authors www.springer.com/00266 .
09:36
Salvianolic acid B suppresses hepatic fibrosis. "IndyWatch Feed Health"
PMID: Acta Pharmacol Sin. 2023 Jun ;44(6):1191-1205. Epub 2023 Jan 10. PMID: 36627345 Abstract Title: Salvianolic acid B suppresses hepatic fibrosis by inhibiting ceramide glucosyltransferase in hepatic stellate cells. Abstract: UDP-glucose ceramide glucosyltransferase (UGCG) is the first key enzyme in glycosphingolipid (GSL) metabolism that produces glucosylceramide (GlcCer). Increased UGCG synthesis is associated with cell proliferation, invasion and multidrug resistance in human cancers. In this study we investigated the role of UGCG in the pathogenesis of hepatic fibrosis. We first found that UGCG was over-expressed in fibrotic livers and activated hepatic stellate cells (HSCs). In human HSC-LX2 cells, inhibition of UGCG with PDMP or knockdown of UGCG suppressed the expression of the biomarkers of HSC activation (-SMA and collagen I). Furthermore, pretreatment with PDMP (40M) impaired lysosomal homeostasis and blocked the process of autophagy, leading to activation of retinoic acid signaling pathway and accumulation of lipid droplets. After exploring the structure and key catalytic residues of UGCG in the activation of HSCs, we conducted virtual screening, molecular interaction and molecular docking experiments, and demonstrated salvianolic acid B (SAB) from the traditional Chinese medicine Salvia miltiorrhiza as an UGCG inhibitor with an ICvalue of 159M. In CCl-induced mouse liver fibrosis, intraperitoneal administration of SAB (30mgkgd, for 4 weeks) significantly alleviated hepatic fibrogenesis by inhibiting the activation of HSCs and collagen deposition. In addition, SAB displayed better anti-inflammatory effects in CCl-induced liver fibrosis. These results suggest that UGCG may represent a therapeutic target for liver fibrosis; SAB could act as an inhibitor of UGCG, which is expected to be a candidate drug for the treatment of liver fibrosis.
09:33
Salvianolic acid B attenuates tubulointerstitial fibrosis. "IndyWatch Feed Health"
PMID: Pharm Biol. 2023 Dec ;61(1):23-29. PMID: 36524761 Abstract Title: Salvianolic acid B attenuates tubulointerstitial fibrosis by inhibiting EZH2 to regulate the PTEN/Akt pathway. Abstract: CONTEXT: Salvianolic acid B (SAB) can alleviate renal fibrosis and improve the renal function.OBJECTIVE: To investigate the effect of SAB on renal tubulointerstitial fibrosis and explore its underlying mechanisms.MATERIALS AND METHODS: Male C57 mice were subjected to unilateral ureteric obstruction (UUO) and aristolochic acid nephropathy (AAN) for renal fibrosis indication. Vehicle or SAB (10mg/kg/d, i.p.) were given consecutively for 2weeks in UUO mice while 4weeks in AAN mice. The serum creatinine (Scr) and blood urine nitrogen (BUN) were measured. Masson's trichrome staining and the fibrotic markers (FN and-SMA) were used to evaluate renal fibrosis. NRK-49F cells exposed to 2.5ng/mL TGF-were treated with SAB in the presence or absence of 20M 3-DZNep, an inhibitor of EZH2. The protein expression of EZH2, H3k27me3 and PTEN/Akt signaling pathway in renal tissue and NRK-49F cells were measured by Western blots.RESULTS: SAB significantly improved the levels of Scr by 24.3% and BUN by 35.7% in AAN mice. SAB reduced renal interstitial collagen deposition by 34.7% in UUO mice and 72.8% in AAN mice. Bothandstudies demonstrated that SAB suppressed the expression of FN and-SMA, increased PTEN and decreased the phosphorylation of Akt, which were correlated with the down-regulation of EZH2 and H3k27me3. The inhibition of EZH2 attenuated the anti-fibrotic effects of SAB in NRK-49Fs.CONCLUSION: SAB might have therapeutic potential on renal fibrosis of CKD through inhibiting EZH2, which encourages further clinical trials.
09:30
Salvianolic acid B exerts an anti-hepatocellular carcinoma effect. "IndyWatch Feed Health"
PMID: Eur J Pharmacol. 2023 Jan 15 ;939:175423. Epub 2022 Dec 9. PMID: 36509132 Abstract Title: Salvianolic acid B exerts an anti-hepatocellular carcinoma effect by regulating the Hippo/YAP pathway and promoting pSmad3L to pSmad3C simultaneously. Abstract: Salvianolic acid B (Sal B) is a component obtained from Salvia miltiorrhiza and is empirically used for liver diseases. The TGF-/Smad and Hippo/YAP pathways may interact with each other in hepatocellular carcinoma (HCC). Previously, we found that Sal B mediates the TGF-/Smad pathway in mice and delays liver fibrosis-carcinoma progression by promoting the Hippo/YAP pathway has not been determined. Therefore, we used a DEN/CCl/CHOH-induced liver cancer model in mice to analyze liver index and tumor incidence, detect AST and ALT serological markers, observe liver pathology and the number of Ki67-positive cells to evaluate the anti-HCC effect of Sal B in vivo. We used a TGF--induced HepG2 cell model, and applied an MST1/2 inhibitor, XMU-MP-1, to detect the changes in pSmad3C/pSmad3L signaling induced by MST1/2 inhibition. Sal B significantly inhibited tumorigenesis in DEN/CCl/CHOH-induced mice in vivo, and suppressed the growth of HepG2 cells by inhibiting cell proliferation and migration in vitro. Here, our study also validated the role of Sal B in reversing XMU-MP-1-induced proliferation and migration of HepG2 cells in vitro. Most importantly, we elucidated for the first time the potential mechanism of Sal B against HCC via the Hippo/YAP pathway, which may be specifically related to upregulation of MST1 and inhibition of its downstream effector protein YAP. In conclusion, these findings indicate that Sal B possesses anti- HCC effects both in vivo and in vitro by regulating the Hippo/YAP pathway and promoting pSmad3L to pSmad3C synchronously.
09:23
Salvianolic acid B protects cardiomyocytes from ischemia/reperfusion injury. "IndyWatch Feed Health"
PMID: Int Heart J. 2022 ;63(6):1176-1186. PMID: 36450557 Abstract Title: Salvianolic Acid B Protects Cardiomyocytes from Ischemia/Reperfusion Injury by Mediating circTRRAP/miR-214-3p/SOX6 Axis. Abstract: Circular RNAs (circRNAs) are a class of powerful regulators of gene expression. This study aimed to determine whether circTRRAP (hsa_circ_0081241) was implicated in the cardioprotective effects of salvianolic acid B (Sal B) against myocardial ischemia/reperfusion (I/R) injury and its associated mechanism.Cell viability was analyzed using Cell Counting Kit-8 (CCK-8), and flow cytometry was conducted to evaluate cell cycle progression and cell apoptosis. The leakage of lactic dehydrogenase (LDH), production of malondialdehyde (MDA), and activity of superoxide dismutase (SOD) were measured using their corresponding commercial kits to analyze cell death and oxidative stress.I/R treatment suppressed viability and cell cycle progression and induced the apoptosis and oxidative stress of AC16 cardiomyocytes, whereas Sal B protected AC16 cardiomyocytes against I/R injury. I/R upregulated circTRRAP expression, whereas Sal B dose-dependently reduced the circTRRAP level in AC16 cardiomyocytes. The protective effects of Sal B in I/R-induced AC16 cardiomyocytes were overturned by the overexpression of circTRRAP. CircTRRAP negatively regulated miR-214-3p expression by binding to it in AC16 cardiomyocytes. The circTRRAP overexpression-mediated effects were reversed by the addition of miR-214-3p mimics in AC16 cardiomyocytes. MiR-214-3p targeted the 3'-untranslated region (3'UTR) of SOX6, and SOX6 was regulated by the circTRRAP/miR-214-3p axis in AC16 cardiomyocytes. SOX6 knockdown overturned the circTRRAP overexpression-induced effects in AC16 cardiomyocytes.In conclusion, the silence of circTRRAP was implicated in Sal B-mediated cardioprotective effects against I/R injury by regulating the miR-214-3p/SOX6 axis.
09:20
CHD Sues Major Media Organizations Alleging Free Speech and Antitrust Violations "IndyWatch Feed Health"
Children's Health Defense sued members of the Trusted News Initiative alleging they violated antitrust laws and the U.S. Constitution when they collectively colluded with others to censor online news
09:19
CHD Sues Major Media Organizations Alleging Free Speech and Antitrust Violations "IndyWatch Feed Health"
Originally published on www.childrenshealthdefense.org
by Brenda Baletti, Ph.D.
Children's Health Defense on Wednesday sued members of the Trusted News Initiative in the U.S. District Court in Louisiana, alleging they violated antitrust laws and the U.S. Constitution when they collectively colluded with tech giants to censor online news.
09:18
Nobiletin probably plays a vital role in the hypoglycemic effect and pancreatic islets protection. "IndyWatch Feed Health"
PMID: Mol Nutr Food Res. 2023 Mar 12:e2200289. Epub 2023 Mar 12. PMID: 36906890 Abstract Title: Hypoglycemic Effect of Nobiletin via Gut Microbiota-Metabolism Axis on Hyperglycemic Mice. Abstract: SCOPE: Prediabetes and diabetes are major public health problems worldwide without specific cure currently. Gut microbes have been recognized as one of the vital therapeutic targets for diabetes. The exploration that nobiletin (NOB) whether affects gut microbes provides a scientific basis for its application.METHODS AND RESULTS: A hyperglycemia animal model is established using high-fat-fed ApoEmice. After 24 weeks of NOB intervention, the level of fasting blood glucose (FBG), glucose tolerance, insulin resistance, and glycosylated serum protein (GSP) are measured. Pancreas integrity is observed by hematoxylin-eosin (HE) staining and transmission electron microscopy. 16s RNA sequencing and untargeted metabolomics are to determine the changes of intestinal microbial composition and metabolic pathways. The levels of FBG and GSP in hyperglycemic mice are effectively reduced. The secretory function of pancreas is improved. Meanwhile, NOB treatment restored the gut microbial composition and affected metabolic function. Furthermore, NOB treatment regulates the metabolic disorder mainly through lipid metabolism, amino acid metabolism, and Secondary bile acid metabolism, etc. In addition, it is possibly existed mutual promotion between microbe and metabolites.CONCLUSION: NOB probably plays a vital role in the hypoglycemic effect and pancreatic islets protection by improving microbiota composition and gut metabolism.
09:14
An investigation into the mechanism of nobiletin's inhibition of papillary thyroid cancer. "IndyWatch Feed Health"
PMID: Eur Rev Med Pharmacol Sci. 2023 Feb ;27(4):1553-1564. PMID: 36876711 Abstract Title: An investigation into the mechanism of nobiletin's inhibition of papillary thyroid cancer using network pharmacology analysis and experimental pharmacology. Abstract: OBJECTIVE: Surgery and radioactive iodine therapy are the main treatments for papillary thyroid carcinoma (PTC), and effective drugs are lacking. As a promising natural product, nobiletin (NOB) has a wealth of pharmacological activities like anti-tumor, antivirus, and other effects. In this research, bioinformatics methods and cellular assays were combined to explore how NOB inhibited PTC.MATERIALS AND METHODS: Our NOB targets were derived from three databases, including the SwissTargetPrediction database, Traditional Chinese Medicine System Pharmacology Database, and the TargetNet server. Four databases were used to identify disease-related targets: GeneCards, PharmGkb, Online Mendelian Inheritance in Man, and DisGeNET. Finally, cross-targets of disease and drug were deemed as pharmacological targets, and they were used for GO and KEGG enrichment analysis. STRING and Cytoscape were applied for PPI Network and core Targets Ranking. Molecular docking analysis validated binding affinity values for NOB and core targets. By using cell proliferation and migration assays, NOB was assessed for its effects on PTC proliferation and migration phenotype. Western blot validated the downregulation of the PI3K/Akt pathway.RESULTS: (1) Preliminarily, 85 NOB targets were predicted for NOB intervention in PTC. (2) Our core target screening identified TNF, TP53, and EGFR, and our molecular docking results confirmed good binding between NOB and protein receptors. (3) NOB inhibited proliferation and migration of PTC cells. PI3K/AKT pathway target proteins were downregulated.CONCLUSIONS: (1) Bioinformatics analyses revealed that NOB may inhibit PTC by regulating TNF, TP53, EGFR and PI3K/AKT signalling pathway. (2) As evidenced by cell experiments, there was an inhibition of proliferating and migrating PTCs by NOB via the PI3K/AKT signalling pathway.
09:12
Evaluation of the possible protective role of nobiletin against arsenic-induced liver damage. "IndyWatch Feed Health"
PMID: Toxics. 2023 Jan 24 ;11(2). Epub 2023 Jan 24. PMID: 36850985 Abstract Title: Evaluation of the Possible Protective Role of Nobiletin against Arsenic-Induced Liver Damage in Male Albino Rats. Abstract: Arsenic (As) is a toxic contaminant present in organic and inorganic forms in the environment. Nobiletin (NOB) is a polymethoxy flavone that has recently gained substantial consideration due to its curative impacts. The present experiment was conducted to assess the hepatoprotective efficiency of NOB on As-generated hepatotoxicity. Twenty-four adult rats were equally distributed into four groups and designated as control, As (50 mg/kg)-treated, As + NOB (50 mg/kg and 25 mg/kg, respectively), and NOB (25 mg/kg)-treated groups. After 30 days, experimental animals were decapitated, then blood and tissue samples were collected for further analysis. The group treated with As showed a significant decrease in the activity of antioxidant enzymes, including catalase (CAT), superoxide dismutase (SOD), peroxidase (POD), glutathione (GSH), glutathione reductase (GSR), and total antioxidant status (TAS), and a substantial increase in the accumulation of As in liver tissues, levels of total oxidant status (TOS), hydrogen peroxide (HO), and lipid peroxidation (TBARS). Significant increases in alanine aminotransferase (ALT), alkaline phosphatase (ALP), and aspartate aminotransferase (AST) levels were observed in As-treated rats. Moreover, nuclear factor (NF)-B, tumor necrosis factor (TNF)-, interleukin (IL)-1, interleukin (IL)-6, and cyclo-oxygenase (COX)-2 activity, as well as the levels of pro-apoptotic markers (Bax, Caspase-3, and Caspase-9) were increased on exposure to As. In contrast, the anti-apoptotic marker (Bcl-2) level was significantly decreased. As administration showed a significant disturbance in hepatic tissue histology. However, cotreatment of NOB with As considerably increased the antioxidant enzyme activity, with a noteworthy reduction in the deposition of As in hepatic tissues, TBARS, and HOlevels. NOB-administrated rats showed considerable recovery in terms of inflammation, apoptosis, and histological damage. Hence, NOB can be considered a useful curative compound due to its medicinal properties against As-prompted hepatotoxicity.
08:53
08:46
The Lion of Chaeronea "IndyWatch Feed Literature"
Nagoya Castle, Tsuchiya Kitsu, 1937
08:38
GreenMedInfo and the Future of Natural Health "IndyWatch Feed Health"
Visit our Re-post guidelines
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The future of GreenMedInfo.com, and natural health advocacies as a whole, is uncertain. Will you be part of keeping our resource alive and well, as well as always improving, long into the future?
For the past 16 years, GreenmedInfo has been dedicated to providing you with evidence-based natural healing information. We are the only natural health resource of its kind that provides users with direct access to meticulously researched articles on health and wellness, curated research abstracts, and breaking natural health news. And all of this information is available for free.
08:38
This is how awesome Real Estate investments are in hyperinflation Weimar example "IndyWatch Feed Spiritual"
by Quant2011, Food and energy eats
most of peoples income. Veeery little is left for rentals
/ luxury furniture and yep, probably for things like iphones,
pharma drugs, new shiny cars and soooo many things corporations
sell. 
So now you tell me, that in hyperinflation (fiat collapse) housing
will rise in price the same as Gold/silver. Sure, hahaha...
Source:
https://www.investmentwatchblog.com08:30
It Isnt Just The Economy That Is On The Verge Of Collapse "IndyWatch Feed Survival"
This article was originally published by Michael Snyder at The Economic Collapse Blog.
We are in far more trouble than most people realize. In recent months, our rapidly growing economic problems have gotten a lot of attention, and without a doubt, our economy is heading into really hard times.
The greatest debt bubble in the history of the world has started to implode, and the end of this mega-cycle is going to cause an immense amount of pain. But if every other element of our society was strong, we could survive that. It may surprise a lot of you to hear me say that, but it is true. If all that we were facing was an economic collapse, it would cause an enormous amount of turmoil in this country but we would make it through.
Unfortunately, we are not just facing an economic collapse.
I like to call what we are facing the everything collapse because virtually every element of our society is steadily breaking down right in front of our eyes.
So once our economic and financial systems implode, it wont just be a matter of patching them up and returning to normal, because normal doesnt exist anymore.
Let me give you an example of what I am talking about. The president of Giant Food just admitted to the Washington Post that theft at his stores is completely out of control
Giant Food president Ira Kress said that theft and violence have risen significantly over the past several years.
To say [theft has] risen tenfold in the last five years would not be an understatement, Kress noted, according to the Washington Post, which also reported that the man said that violence has increased exponentially.
Giant has more than 160 locations, with stores located in Maryland; Virginia; Washington, D.C.; and Delaware, according to its website.
When I was much younger, I would often shop at Giant Food.
In those days, I never witnessed a single shoplifting incident.
But now systematic looting is happening on an industrial scale all ove...
08:17
An AI Chatbot Will Now Take Your Order At Wendys "IndyWatch Feed Arts"
I live in the middle of America and have already had my McDonalds order taken by a robot, so Im assuming others have also had the experience.
Its weird, for sure, but also one hasnt messed up my order yet. So thats something.
Wendys is now getting in on the game, too, and it seems theres no turning back.
Image Credit: iStock
The chatbot in their drive-thru was developed by Googles cloud computing division and claims with it, they are able to streamline Wendys business.
Wendys CEO Todd Penegor has a very high opinion of the product.
...08:00
Celsius Sets New Standard: $1 Billion In ETH Staked As Deposits Show No Sign Of Slowing "IndyWatch Feed Crypto"
Celsius, a popular lending platform, has made significant moves in staking Ethereum (ETH) as they stake almost $1 billion worth of the cryptocurrency. According to the Blockchain intelligence company Arkham Intel, In the past 24 hours alone, Celsius has staked over $600 million worth of ETH, with no signs of slowing down. This represents a massive on-chain flow, and the rate of deposits continues to increase.
Celsius Goes All-In On ETH
Celsius address was the largest withdrawer when Lido (LDO) opened withdrawals in mid-May, withdrawing over 400,000 ETH, worth $800 million. They held this ETH in the Unstaking wallet for two weeks, declaring their intent to stake with institutional provider Figment instead.
Around 24 hours ago, Celsius separated the ETH from the unstaking wallet into two separate deposit wallets. One wallet is marked Celsiuss ETH2 Deposit wallet, while the other wallet is labelled Staked ETH and deposits to Figment. Celsiuss staking wallet has seen over $400 million worth of ETH inflows over the past 24 hours, with continual deposits made every few minutes.
Figment is a staking and infrastructure provider for blockchain networks, including Ethereum. The company provides institutional-grade staking infrastructure and tools for investors and companies looking to participate in the proof-of-stake (PoS) networks.
Furthermore, the infrastructure provider offers a range of staking services, including delegated staking, which allows investors to delegate their tokens to a validator node to generate rewards without having to run their own node. The company also provides a range of developer tools, APIs, and analytics to help users better understand and manage their staking activities.
Morevoer, the wallet provided to Celsius by Figment has seen over $215 million worth of ETH. In total, Celsius has deposited over $600 million worth of ETH, with the Celsius Staking wallet still holding over $150 million worth of ETH, and around $60 million worth of ETH left in the wallet they used to unstake fr...
07:32
Marathon Digital Mined 77% More Bitcoin in May With the Help of Its Software "IndyWatch Feed Crypto"
Marathon Digital CEO Fred Thiel interview at Bitcoin conference in Miami (CoinDesk)
07:30
Intuitive Astrology: Saturn Retrograde June-November 2023 "IndyWatch Feed Spiritual"
Saturn is bound for the underworld, traveling retrograde from June 17 until November 4, 2023, in the sign of Pisces.
It is typical for Saturn to spend about 6 months of the year in retrograde, but this retrograde is extra significant as its the first time Saturn will retrograde through Pisces since it entered this zodiac back in March. Plus, just hours after Saturn descends into its underworld journey, we have the Gemini New Moon, which will heighten the starting energy of this retrograde.
Lets take a deep dive into what Saturn Retrograde 2023 will bring and how the first Saturn Retrograde in Pisces will manifest.
Saturn Retrograde 2023
Saturn is considered the master teacher of the zodiac. It brings some challenging lessons, but they push us to grow and reach the fullest of our potential. Whenever Saturn is active, it can bring some harsh awakenings but also many rewards if we are willing to step up to the plate and do the work.
Saturn guides us to take responsibility for our lives, own up to our actions and decisions, and learn how to create boundaries. It is a very straightforward, black-and-white energy that inspires us to be ambitious, aim high, and excel in all that we are destined to. Saturn can also represent issues with masculinity, father figures, or authority.
As Saturn travels retrograde, it guides us to look over our past actions and see where we have avoided, or perhaps forgotten, to take responsibility or set boundaries. As our master teacher, Saturn looks back over the last few months, checking to see if we have done our homework and are embracing the lessons provided.
Saturn Retrograde in Pisces 2023
Saturn first entered Pisces on March 8, 2023. So this is the period that will be highlighted under this 2023 retrograde. From March 8 to June 17, how have you grown? How have you matured? What lessons have come to the surface?
We may find past events since March 2023, resurfacing so we can reassess or reevaluate. Issues around our creativity, limitations and blocks, or our emotional health may also come to the surface.
Saturn wants us to be responsible for our actions and the life we desire to lead. If things are not going how you want them to, Saturn makes you confront them and pushes you to take the steps needed to shift your life to a better place.
Saturn can be a slow energy, especially when in retrograde, so this can be a process that requires patience and time. We may feel stuck or unsure of how to proceed, but this feeling of stuckness is only because we need to give ourselves time to reach the core of the issue.
During a Saturn Retrograde, if you feel stuck, its because you are meant to be focusing on where you currently are.
As Saturn trave...
07:30
Crypto Biz: Six months on from FTX, Tether mines BTC, and Nvidias AI superchips "IndyWatch Feed Crypto"
This weeks Crypto Biz looks at the crypto industry since the FTX collapse, Tethers Bitcoin mining in Latin America, Tabis funding round and Nvidias artificial intelligence machines.
07:00
A Museums Worker Take on Repatriations "IndyWatch Feed Spiritual"
Lyonel Perabo reviews "The Museum of Other People" by Adam Kuper and uses his experiences as a museum guide to consider the problems of repatriating artifacts and artworks.
Continue reading A Museums Worker Take on Repatriations at The Wild Hunt.
06:47
Why Did Bitcoins Price Rise? BTC Hovers Over $27K as Investors Shrug Off Hot Jobs Data "IndyWatch Feed Crypto"
Bitcoin daily chart (CoinDesk Market Index)
06:45
US lawmakers aim for crypto regulatory clarity with proposed bill putting the screws to SEC "IndyWatch Feed Crypto"
The framework under the bill would allow certain tokens to qualify as digital commodities if they were decentralized and crack down on the SECs previous approach to crypto.
06:31
Google Pixel 7a Review: The Mid-Range Champ "IndyWatch Feed Photography"
The Google Pixel 7a is a rarity. It's a mid-range phone that performs above that spec in many areas, making it hard to pass especially when the price starts at $499.
06:30
Arbitrum price soars after DeFi whale address resumes ARB accumulation "IndyWatch Feed Crypto"
ARBs price notched a double-digit gain after a popular DeFi whale address resumed buying the governance token, but is the rally sustainable?
06:25
Losses from crypto rug pulls outpaced DeFi exploits in May: Finance Redefined "IndyWatch Feed Crypto"
The top 100 DeFi tokens had a bullish last week of May, with most of the tokens recovering from two weeks of bearish pressure.
06:22
Mercado Bitcoin, Brazil's Largest Crypto Exchange, Receives License as a Payment Institution "IndyWatch Feed Crypto"
Roberto Dagnoni, CEO and Executive Chairman at 2TM, owner of Mercado Bitcoin. (2TM)
06:15
High School Seniors Playfully Prank Principal With Unexpected Sleepover at Her House "IndyWatch Feed Arts"
High School Seniors Playfully Prank Principal With Unexpected Sleepover at Her House
Every year, high school seniors across the country celebrate their graduation with a creative prank. While most of the time this involves decorating their campus, dressing up, or other antics, a group of students at St. Andrew's School in Middletown, Delaware, thought outside the box. The mischievous seniors snuck into their principal's house late ant night and camped out in her living room area, leading to a stunning surprise that has now gone viral.
In the video, we can see the St. Andrew's school principal, Mrs. Joy McGrath opening the door and being confronted by a sea of giddy teenagers. Understandably shocked, she quickly shuts the door to compose herself. When she returns, the first thing she says to the seniors is, Good morning, little bunnies. The room fills with laughter and McGrath quickly singles out one person and adds, You are in the most trouble. Commenters guess that she is referring to her husband, who was probably helping the seniors with their scheme.
How long have you been here? McGrath asks the students. They reveal that they snuck in around 1 a.m., and the principal is incredulous that she didn't hear them enter the house. After the initial shock wears off, it's clear that McGrath has a close bond with her students, as they share many more jokes and laughs in the video. This is the most beautiful thing I've ever seen, she tells them.
The epic idea was concocted after McGrath invited the teens to her house at midnight after their senior prom. Mrs. McGrath invited all of us over for breakfast at 12 a.m., KaiChun Austin Chuange, the student who filmed the prank, says. Someone joked that they wouldn't mind going to bed right there in the living room. Then, a couple of us glanced at each other like, hmmmm.' Fortunately, McGrath is a heavy sleeper, as she mentioned that she even sl...
06:10
Privacy-focused Aleo blockchain gets new wallet as mainnet launch approaches "IndyWatch Feed Crypto"
The wallet developer also raised $4.5 million from Hack VC and other firms to further advance ZK-based enterprise solutions.
06:09
She Told Her Neighbor That Her and Her Roommates Arent Babysitters. Was She Wrong? "IndyWatch Feed Arts"
Its funny how some people think they can pawn off their kids on other folks and not even give it a second thought.
Well, I guess I shouldnt say that its funny because its actually pretty ANNOYING.
And the woman who wrote this story seems to be pretty fed up with her neighbor.
But did she act like an a**hole?
Take a look at what she had to say and see what you think.
AITA for telling my neighbor that my roommates and I arent babysitters ?
I (20f) share an apartment with Casey (24m) , Nellie(19f) and Hannah (21f) along with Hannahs 8 month old daughter. The issue at hand concerns our neighbors.
John (30m) and his wife Jane (25f) have a set of twins that are a year old . So sometimes , Hannah and they will have a playdate with the younger ones . But recently , theyve been using the play dates as a way to dump their kids on Hannah and the rest of us . Sometimes for hours without answering the phone .
Now , I love kids and would be more than happy to babysit them . But , we are all ether working , in college or both. So more often weve ether been late to class or work cause we cant contact John or Jane .
Yesterday , the four of us were preparing to go out for lunch and get some shopping done . As we were leaving , John stopped us and said he needed Hannah to watch his kids while he went out to see a movie .
I told him we arent babysitters and if they the kids with us again without answering. Wed call social services , to which he called a bunch of spineless leeches .
The other parents in the complex said that we were harsh to new parents and to have more compassion.
Heres what folks had to say about this on Reddit.
One person made a good point about whats...
06:00
Bitcoin Is Becoming Greener At An Unexpected Pace, Good For BTC Price? "IndyWatch Feed Crypto"
Bitcoin, the worlds most valuable cryptocurrency, is going green, and the pace at which the network has reduced its carbon emissions in the past three years has been noted by climate activists. Nonetheless, how this could impact BTC prices and attract technology firms like Tesla, the electric automobile manufacturer, is yet to be seen.
Carbon Emission Associated With Bitcoin Miners Rapidly Falling
As of late May, on-chain data from Woonomic shared by Daniel Batten, a climate technology investor, and activist, noted that the amount of Carbon emission associated with Bitcoin mining has fallen by nearly 50% from 601g/kWh to 299g/kWh in three short years.
It should be observed that the Bitcoin hash rate and prices have been rising steadily during this time. In the last quarter of 2021, the Bitcoin price soared to as high as $69,000 before collapsing to below $16,000 in November 2022. Although prices have since recovered, soaring to as high as $31,000 in April 2023, the hash rate has been steadily rising over the years.
In proof-of-work networks like Bitcoin and Litecoin, the hash rate relays the computing power dedicated to the network in real time. It is a variable that makes the network secure and robust against third-party attacks, and can also be used to gauge the pace at which the Bitcoin platform consumes energy.
Miners channel computing power as hash rate to secure the Bitcoin network. They need this to verify transactions in exchange for network rewards. The more the hash rate, the higher the chance of earning a block and, thus, the 6.25 BTC every 10 minutes.
However, the tough competition for the block rewards has been partly blamed for environmental degradation and carbon emissions from miners. To stay competitive, Bitcoin miners have to operate gear that is energy-intensive. Critics have always maintained that electricity powering them is from coal and other non-renewable sources.
As of June 2, the Bitcoin Energy Consumption Index shows that 105.23 TWh powers Bitcoin. It is the same amount of electricity consumed by Kazakhstan. The resulting Carbon emission, they add, stands at 58.69 Mt CO2, comparable to that emitted by Libya.
However, data...
06:00
U.S. House Republicans Push for Crypto Oversight With Bill to Make SEC Play Ball "IndyWatch Feed Crypto"
U.S. Securities and Exchange Commission (Jesse Hamilton/CoinDesk)
05:47
Broncolors New $20K Dual-Power Pack Works In Studio or On Location "IndyWatch Feed Photography"
Broncolor has announced the new Satos power packs that use a unique dual-power system that can be equipped with conventional power supplies for studio use or with high-performance batteries for on-location use -- or a combination of both.
05:46
Astrophotographer Addresses Fake Image Allegations From Flat Earthers "IndyWatch Feed Photography"
Backyard astrophotographer Andrew McCarthy took to Twitter to address accusations that his images are "fake" following his latest photo of the ISS crossing the Moon.
05:42
Did the British Museum Cut Ties With Its Oil Sponsor? "IndyWatch Feed Arts"
The Guardian reported today that after nearly three decades, the British Museums contentious sponsorship deal with British Petroleum (BP) is ending. The news would signify a near-complete withdrawal of the oil giant from the UK arts world, as partnerships with other publicly funded institutions including the Tate and the National Portrait Gallery have also come to a close in recent years in the wake of pressure from anti-fossil fuel activists.
The Guardian c...
05:42
Evertas expands crypto insurance offerings to include mining and raises limits "IndyWatch Feed Crypto"
Crypto insurance underwriter Evertas will increase coverage limits to $420 million per policy while adding additional mining coverage.
05:39
Price analysis 6/2: BTC, ETH, BNB, XRP, ADA, DOGE, MATIC, SOL, DOT, LTC "IndyWatch Feed Crypto"
Bitcoin and most major altcoins are witnessing subdued price action, indicating a lack of buying interest from the larger players.
05:36
Tara Asgar Embraces Freedom in Sadness "IndyWatch Feed Arts"
This article is part of Hyperallergics Pride Month series, featuring an interview with a different transgender or nonbinary emerging artist every weekday throughout the month of June.
For the second installment of our monthlong series, were shining a spotlight on the work of Tara Asgar, a Bangladeshi trans woman, asylum seeker, and artist currently based in Brooklyn. Born in Dhaka, Asgar became involved in local LGBTQIA+ community organizing to push back against the conservative and state-sponsored persecution of queer people. Asgar was involved in mobilizing Bangladeshs first-ever Pride Parade in 2014 and creating safe spaces for at-risk individuals. She identifies herself as one of the first openly queer visual artists in the country.
In 2016, the artist witnessed the murder of LGBTQIA+ activist Xulhaz Mannan and friend Mahbub Rabbi Tonoy by an Islamist militant group. She narrowly escaped the at...
05:25
The Variety of Stones Used in Construction "IndyWatch Feed Diy"
There are three groups of stone used for construction: igneous, metamorphic, and sedimentary stones.
Igneous rock, such as granite, is mainly composed of volcanic material. Magma beneath the earths surface hardens as it combines with mineral vapors and liquids to form a variety of geological formations.
This coarse-grained stone is predominantly composed of
quartz and feldspar. Crystallization gives granite its
characteristic color flecks; the longer the molten rock has to
settle, the larger the color granules become. Granite is a popular
building material primarily due to its resilience, endurance, and
minimal maintenance requirements. It is good for flooring and
columns, but is quite expensive compared to other frequently used
natural stones.
Metamorphic stones are produced by a long time exposure to a combination of pressure, temperature, and mineral deposits. The most frequently utilized metamorphic natural stone is marble.
Marble is found in the mountainous regions of numerous
countries, including Canada, Italy, Germany, Spain, and the United
States. It is a very durable, uniformly textured and can be readily
shaped and sculpted into various forms and then polished. Its
sweeping lines, gorgeous colors, and high polish giv...
05:20
Rare White Bison Born at a State Park in Wyoming "IndyWatch Feed Arts"
Rare White Bison Born at a State Park in Wyoming
Bear River State Park in Wyoming got a new, cute resident recently when one of its bison gave birth to a calf. While there are a lot of bison in the park, this new arrival is particularly interesting because the calf is white. The park received two white bison heifers in 2021, but this is the first calf born on the grounds.
White bison are extremely rare, with the National Bison Association stating that they're a one in a million occurrence. Due to this rarity, they are actually held sacred by many Native American tribes. However, this calfwhich has yet to be namedisn't as rare as you'd think.
In actuality, its white coloration is not due to albinism but is actually the result of mixed heritage. When bison were hunted to near extinction in the late 1800s, cattle inbreeding was used to raise the population levels. According to park superintendent Tyfani Sager, most bison we see today have some cattle genetics mixed in.
This still makes the white calf rare but not genetically unique and not nearly as rare as an albino bison. At the moment, the young calf is thriving and sticking close to its mother. Park officials have yet to determine its sex.
Were not sure if its a bull calf or a heifer calf, Sager said. Theyre real furry and its hard to tell right off the bat.
Currently, the 328-acre park is home to 10 bison and five calves. And hopefully, the young calf will have another white calf to play with when the park's second white bison is expected to breed next spring.
Bear River State Park is home to two white bison heifers, one of which gave birth to a rare white calf.
h/t: [CBS News]
Related A...
04:55
What AI Governance Can Learn From Cryptos Decentralization Ethos "IndyWatch Feed Crypto"
WASHINGTON, DC - MAY 16: Samuel Altman, CEO of OpenAI, appears for testimony before the Senate Judiciary Subcommittee on Privacy, Technology, and the Law May 16, 2023 in Washington, DC. The committee held an oversight hearing to examine A.I., focusing on rules for artificial intelligence. (Photo by Win McNamee/Getty Images)
04:54
Binance Market Share Drops to Lowest Level Since October "IndyWatch Feed Crypto"
Sage Young/CoinDesk
04:48
The Nikon Z8 Wont Work With Some Third-Party Batteries: Report "IndyWatch Feed Photography"
A camera producing an error when photographers use unofficial third-party batteries isn't anything new. However, reports of possible digital rights management (DRM) being used in Nikon batteries, at least with its new Z8 camera, is worth taking a closer look at.
04:42
Fluoride directive deferred by council "IndyWatch Feed Health"
The Grey District Council has deferred a government directive that it add fluoride to the Greymouth drinking water supply.
The Government changed the rules in 2021, removing the decision-making on fluoridation from local councils. Last year, the Ministry of Health advised the Grey council it was required to fluoridate its water supplies.
However, councillors this week voted to seek feedback from the community, thereby deferring spending the required $900,000 on installing a fluoridation plant.
Group manager operations Aaron Haymes told councillors earlier this week staff had pushed back on the initial request.
We said we believe the community here shouldnt have to pay for that infrastructure because it is going to be handed over to the new water entity to manage [under three waters changes], Mr Haymes said.
However, he conceded, we dont think we can hold off for another two years. We think we have to commit to installing the plant.
Blackball water is exempt from fluoridation as the population threshold of 500 means only the greater Greymouth area will require the plant.
Mayor Tania Gibson was not pleased.
This is getting mandated on to us again by central Government and our community hasnt been consulted. I dont believe we have to accept it through this process.
Cr Jack OConnor agreed, saying the issue had not been brought up in the recent consultation round and it would appear like we are hiding something we are not at all..
Cr Rex MacDonald asked about the financial and reputational risk if the council defied the government directive.
Mr Haymes cautioned there would probably be some type of intervention,and there will definitely be some reputational consequences.
Mayor Gibson asked pointedly whether that was from the government point of view, or from the community who havent had a say.
Asked by Cr Robert Mallinson if the council was acting legally, chief executive Paul Morris said it was, adding that local government once had the power to determine whether water was fluoridated, until it was taken away and given to the director-general of health..
You do have an opportunity to gauge your communitys feelings thats feedback that can be given to the Ministry of Health.
By Meg Fulford
*Original full-text article online at: https://www.odt.co.nz/regions/west-coast/fluoride-directive-deferred-council
04:39
Angela Cassie to Depart as Interim CEO of National Gallery of Canada "IndyWatch Feed Arts"
Angela Cassie, who stepped in as interim director and CEO of the National Gallery of Canada in June 2022, after Sasha Suda departed to lead the Philadelphia Museum of Art, is leaving both roles. According
04:33
CleanSparks Latest Update Reveals Major Boost In BTC Mined Due To Fees "IndyWatch Feed Crypto"
CleanSpark, Inc., a publicly traded bitcoin mining company, has released its May 2023 bitcoin mining and operations update, revealing significant growth in both its bitcoin holdings and revenue. The company's bitcoin holdings grew by 44% in May, reaching a total of 451 BTC. Bitcoin mined during the month increased by 16% to 609 BTC.
CleanSpark's CEO, Zach Bradford, expressed satisfaction with the company's performance, stating, "Not only do we continue to increase the amount of bitcoin in our treasury, but we also surpassed $100 million in revenue for our fiscal year to date."
Bradford also attributed the higher-than-expected bitcoin production to increased operational efficiency and a temporary surge in transaction fees due to increased interest in Ordinals on the blockchain. During this period, CleanSpark's daily bitcoin production reached nearly 30 BTC, almost double its normal daily production.
In terms of operational updates, CleanSpark's 50MW expansion in Washington is progressing according to plan, with the facility expected to be fully operational by the end of June. The company's Sandersville site expansion is also underway, with preparations being made for the addition of over 6 EH/s to CleanSpark's mining operations.
To fund its growth and operations, CleanSpark sold 471 bitcoins in May, generating approximately $12.9 million in proceeds. The company currently operates a fleet of about 67,196 latest-generation bitcoin miners with a total hashrate of 6.7 EH/s.
CleanSpark described its commitment to expanding its bitcoin mining capacity and capitalizing on market opportunities. The company stated that with its strong performance and increasing bitcoin holdings, it remains well-positioned for future growth in the industry.
04:30
Bloombergs Senior Macro Strategist Predicts More Pain Ahead For Bitcoin "IndyWatch Feed Crypto"
In his latest report titled Crypto Outlook, June 2023, Bloombergs Senior Macro Strategist, Mike McGlone, predicts more pain ahead for Bitcoin (BTC) and the broader cryptocurrency market. McGlone argues that despite a rebound in prices in 2023, the risks for the Bloomberg Galaxy Crypto Index remain tilted downward.
Is Bitcoin Doomed?
According to McGlone, cryptocurrencies face several headwinds, including the potential for a US recession, a potential stock bear market, vigilant central banks, and high interest-rate competition. These factors, combined with the speculative excesses that led to the 2021 peak, suggest that the outlook for the crypto market is bearish.
Furthermore, McGlone points out that Bitcoin weakening in May, along with copper and equities in China, is unusual compared to the stalwart Nasdaq 100 Stock Index. While the potential for the Nasdaq to lift all boats exists, it may contrast with still-rising Fed rate-hike expectations.
Additionally, McGlone suggests that Bitcoin, which is often referred to as digital gold due to its perceived status as a store of value, may not be able to outperform the traditional safe-haven asset in a US economic contraction. This is because Bitcoin is still relatively young compared to gold, which has been used as a store of value for thousands of years. As a result, investors may be more likely to flock to gold during times of economic uncertainty, rather than newer assets like Bitcoin.
Moreover, plunging commodities, producer prices, and bank deposits may serve as deflationary omens of the lags to Federal Reserve tightening. These factors suggest that the risks for the Bloomberg Galaxy Crypto Index are tilted downward, and investors should be cautious.
As reported by NewsBTC on May 22nd, Mike McGlone highlighted the historical patterns of boom and bust in Bitcoin, which are closely tied to liquidity. According to McGlone, Bitcoins current price level of around $27,000 may be at risk of reversion, considering that it was only $7,000 at the end of 2019 before the massive liquidity pump in 2020.
McGlones analysis also indicates that Bitcoins downward trajectory, as demonstrated by its 52-week moving average, contrasts with the upward trend it experienced at the onset of the pandemic. This suggests that the cryptocurrency is susceptible to booms when liquidity is abundant but vulnerable to busts when liquidity is removed.
McGlones latest analysis aligns with his previous thesis that the outlook for Bitcoin and the broader cryptocurrency market is bearish, given the poten...
04:25
CBDC may not be a compelling priority,' says Kenyas central bank "IndyWatch Feed Crypto"
The central bank released its statement in response to comments on a CBDC discussion paper published in February 2022.
04:22
Study Shows That Getting Poor Sleep Can Invite The Boogeyman In "IndyWatch Feed Arts"
We know by now that there are so many health and wellness reasons to try your best to get a good nights rest as often as possible.
And heres one more: regularly getting poor sleep can lead to one believing more strongly in the paranormal.
New research seems to imply that an inability to sleep well could lead to more easily seeing the paranormal in the shadows.
Image Credit: iStock
It joins previous studies that have linked things like...
04:17
CoinDesk Turns 10: The ICO Era What Went Right? "IndyWatch Feed Crypto"
Dan Larimer who led the EOSs $4 billion token sale in 2017, one of the largest of the ICO era.
04:16
Bitcoin Miners Are Probably Selling Their Output at the $28K Level: Matrixport "IndyWatch Feed Crypto"
New and old bitcoin mining rigs. (Eliza Gkritsi/CoinDesk)